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Planta Med 2012; 78(17): 1878-1880
DOI: 10.1055/s-0032-1315369
DOI: 10.1055/s-0032-1315369
Natural Product Chemistry
Letters
Three New Sesquiterpenes with Cytotoxic Activity from Dobinea delavayi
Further Information
Publication History
received 05 May 2012
revised 09 August 2012
accepted 22 August 2012
Publication Date:
21 September 2012 (online)
Abstract
Three new sesquiterpenes dobinins A–C (1–3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1–3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 × 10−5, 4.7 × 10−5, and 5.1 × 10−5 M, respectively.
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