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Planta Med 2012; 78(17): 1851-1856
DOI: 10.1055/s-0032-1315391
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Prenylated Flavonoids from the Roots of Desmodium caudatum and Evaluation of Their Antifungal Activity

Hisako Sasaki
1   Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
,
Yoshiki Kashiwada
1   Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
,
Hirofumi Shibatav
,
Yoshihisa Takaishi
1   Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
› Author Affiliations
Further Information

Publication History

received 09 July 2012
revised 29 August 2012

accepted 31 August 2012

Publication Date:
11 October 2012 (online)

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Abstract

Two new prenylated flavonoids (1, 4) and two new prenylated C-methyl-flavonoids (6, 7), together with four known flavonoids (2, 3, 5, 8), were isolated from the roots of Desmodium caudatum. The structures of the new compounds were elucidated by extensive spectroscopic analyses including 1D-, 2D-NMR and MS. The antifungal activities of five compounds (1, 2, 4, 6, 8) as well as nine flavonoids (9–17) previously isolated from this plant against Aspergillus niger, Penicillium sp., Rhizopus sp., and Trichophyton sp. were evaluated. Compound 6 showed potent antifungal activity against Trichophyton sp. with a minimum inhibitory concentration (MIC) value of 1.95 µg/mL.

Key words

Desmodium caudatum - Fabaceae - prenylated flavonoid - antifungal activity
 

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