We describe the synthesis of four bromo-substituted azabipyridines and two bromo-substituted
azaterpyridines through a series of palladium-catalyzed cross-coupling reactions.
Both the azabipyridine and azaterpyridine heterocycles contain two orthogonal binding
motifs, the value of which has been demonstrated recently in a nanomechanical switch
for triggering organocatalysis. The bromo functionality allows heterocyclic ligands
to be attached to larger frameworks.
Key words
N-heterocycles - palladium catalysis - bipyridine - terpyridine - carbon–carbon coupling