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Synthesis 2012; 44(24): 3822-3828
DOI: 10.1055/s-0032-1316816
DOI: 10.1055/s-0032-1316816
paper
Synthetic Approaches towards 4-Functionalized Estrone Derivatives
Authors
Further Information
Publication History
Received: 05 August 2012
Accepted after revision: 28 September 2012
Publication Date:
05 November 2012 (online)
Abstract
Directed ortho-lithiation of estrone carbamate followed by reaction with electrophiles afforded 2-substituted estrone derivatives. Reductive cleavage of the carbamate group followed by O-allylation and Claisen rearrangement led to new 4-functionalized estrone derivatives.
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