Domino o-Alkylation and Heteroarylation of Iodoarenes: One-Pot Synthesis of Benzocyclohepta[b]indoles

Abstract

A new strategy for the synthesis of benzocyclohepta[b]indoles via a palladium-catalyzed/norbornene-mediated domino intermolecular alkylation/intramolecular heteroarylation of iodoarenes is devised. This approach provides a straightforward route to polycyclic nitrogen-containing heterocycles with fused seven­-membered rings from readily accessible precursors.

Key words

benzocyclohepta[b]indole - domino reaction - norbornene - one-pot synthesis - palladium

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