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Am J Perinatol 2013; 30(07): 579-588
DOI: 10.1055/s-0032-1329686
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Maternal Dietary Nutrient Intake and Risk of Preterm Delivery

Suzan L. Carmichael
1   Division of Neonatology and Developmental Medicine, Stanford University School of Medicine, Stanford, California
,
Wei Yang
1   Division of Neonatology and Developmental Medicine, Stanford University School of Medicine, Stanford, California
,
Gary M. Shaw
1   Division of Neonatology and Developmental Medicine, Stanford University School of Medicine, Stanford, California
,
for The National Birth Defects Prevention Study › Author Affiliations
Further Information

Publication History

25 May 2012

21 August 2012

Publication Date:
03 December 2012 (online)

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Abstract

Objective To examine maternal dietary intake and preterm delivery.

Study Design Data included 5738 deliveries from the National Birth Defects Prevention Study. Odds ratios (ORs) reflected risks of delivery at <32, 32–34, or 35–36 versus ≥37 weeks for maternal intake in the lowest or highest quartile of nutrient intake compared with the middle two.

Results Among deliveries < 32 weeks, many ORs were ≥1.5 or ≤0.7, but few confidence intervals excluded one. ORs were ≥1.5 for lowest quartiles of protein, thiamin, riboflavin, choline, vitamin A, α-carotene, β-carotene, vitamin E, iron, copper, and zinc and for highest quartiles of carbohydrate, glycemic index, and Mediterranean Diet Score. ORs were ≤0.7 for lowest quartiles of glycemic index and betaine and for highest quartiles of protein, alanine, methionine, vitamin B6, betaine, and calcium. Few ORs met these criteria for later preterm deliveries.

Conclusions Results suggested an association of nutrient intake with earlier preterm deliveries.

Keywords

nutrition - pregnancy - preterm delivery
 

  • References

  • 1 Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med 2010; 362: 529-535
    Google Scholar
  • 2 Dunlop AL, Kramer MR, Hogue CJ, Menon R, Ramakrishan U. Racial disparities in preterm birth: an overview of the potential role of nutrient deficiencies. Acta Obstet Gynecol Scand 2011; 90: 1332-1341
    CrossrefPubMedGoogle Scholar
  • 3 Kramer MS, Kahn SR, Platt RW , et al. Antioxidant vitamins, long-chain fatty acids, and spontaneous preterm birth. Epidemiology 2009; 20: 707-713
    CrossrefPubMedGoogle Scholar
  • 4 Bloomfield FH. How is maternal nutrition related to preterm birth?. Annu Rev Nutr 2011; 31: 235-261
    CrossrefPubMedGoogle Scholar
  • 5 Bukowski R, Malone FD, Porter FT , et al. Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med 2009; 6: e1000061
    CrossrefPubMedGoogle Scholar
  • 6 Yoon PW, Rasmussen SA, Lynberg MC , et al. The National Birth Defects Prevention Study. Public Health Rep 2001; 116 (Suppl. 01) 32-40
    PubMedGoogle Scholar
  • 7 Willett WC, Sampson L, Stampfer MJ , et al. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985; 122: 51-65
    CrossrefPubMedGoogle Scholar
  • 8 U.S. Department of Agriculture. Agricultural Research Service. USDA National Nutrient Database for Standard Reference, Release 20. Nutrient Data Laboratory Home Page; 2007. Available at: http://www.ars.usda.gov/ba/bhnrc/ndl . Accessed October 18, 2012
    PubMedGoogle Scholar
  • 9 Trichopoulou A, Kouris-Blazos A, Wahlqvist ML , et al. Diet and overall survival in elderly people. BMJ 1995; 311: 1457-1460
    CrossrefPubMedGoogle Scholar
  • 10 Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003; 348: 2599-2608
    CrossrefPubMedGoogle Scholar
  • 11 Bodnar LM, Siega-Riz AM. A Diet Quality Index for Pregnancy detects variation in diet and differences by sociodemographic factors. Public Health Nutr 2002; 5: 801-809
    PubMedGoogle Scholar
  • 12 Carmichael SL, Yang W, Feldkamp ML , et al; National Birth Defects Prevention Study. Reduced risks of neural tube defects and orofacial clefts with higher diet quality. Arch Pediatr Adolesc Med 2012; 166: 121-126
    CrossrefPubMedGoogle Scholar
  • 13 Carmichael SL, Shaw GM, Yang W , et al; National Birth Defects Prevention Study. Correlates of intake of folic acid-containing supplements among pregnant women. Am J Obstet Gynecol 2006; 194: 203-210
    CrossrefPubMedGoogle Scholar
  • 14 Abu-Saad K, Fraser D. Maternal nutrition and birth outcomes. Epidemiol Rev 2010; 32: 5-25
    CrossrefPubMedGoogle Scholar
  • 15 Peña-Rosas JP, Viteri FE. Effects and safety of preventive oral iron or iron + folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev 2009; (4) CD004736
    PubMedGoogle Scholar
  • 16 Scholl TO, Hediger ML, Schall JI, Fischer RL, Khoo CS. Low zinc intake during pregnancy: its association with preterm and very preterm delivery. Am J Epidemiol 1993; 137: 1115-1124
    PubMedGoogle Scholar
  • 17 Mahomed K, Bhutta Z, Middleton P. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev 2007; (2) CD000230
    PubMedGoogle Scholar
  • 18 Hauth JC, Clifton RG, Roberts JM , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units Network (MFMU). Vitamin C and E supplementation to prevent spontaneous preterm birth: a randomized controlled trial. Obstet Gynecol 2010; 116: 653-658
    CrossrefPubMedGoogle Scholar
  • 19 Rumbold A, Crowther CA. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev 2005; (2) CD004072
    PubMedGoogle Scholar
  • 20 Rumbold A, Crowther CA. Vitamin E supplementation in pregnancy. Cochrane Database Syst Rev 2005; (2) CD004069
    PubMedGoogle Scholar
  • 21 Siega-Riz AM, Promislow JH, Savitz DA, Thorp Jr JM, McDonald T. Vitamin C intake and the risk of preterm delivery. Am J Obstet Gynecol 2003; 189: 519-525
    CrossrefPubMedGoogle Scholar
  • 22 Shaw GM, Carmichael SL, Yang W, Siega-Riz AM. National Birth Defects Prevention Study. Periconceptional intake of folic acid and food folate and risks of preterm delivery. Am J Perinatol 2011; 28: 747-752
    Article in Thieme ConnectPubMedGoogle Scholar
  • 23 Buppasiri P, Lumbiganon P, Thinkhamrop J, Ngamjarus C, Laopaiboon M. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database Syst Rev 2011; (10) CD007079
    PubMedGoogle Scholar
  • 24 Scholl TO, Chen X, Khoo CS, Lenders C. The dietary glycemic index during pregnancy: influence on infant birth weight, fetal growth, and biomarkers of carbohydrate metabolism. Am J Epidemiol 2004; 159: 467-474
    CrossrefPubMedGoogle Scholar
  • 25 Rhodes ET, Pawlak DB, Takoudes TC , et al. Effects of a low-glycemic load diet in overweight and obese pregnant women: a pilot randomized controlled trial. Am J Clin Nutr 2010; 92: 1306-1315
    CrossrefPubMedGoogle Scholar
  • 26 Metzger BE, Lowe LP, Dyer AR , et al; HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008; 358: 1991-2002
    CrossrefPubMedGoogle Scholar
  • 27 McGowan CA, McAuliffe FM. The influence of maternal glycaemia and dietary glycaemic index on pregnancy outcome in healthy mothers. Br J Nutr 2010; 104: 153-159
    CrossrefPubMedGoogle Scholar
  • 28 Haugen M, Meltzer HM, Brantsaeter AL , et al. Mediterranean-type diet and risk of preterm birth among women in the Norwegian Mother and Child Cohort Study (MoBa): a prospective cohort study. Acta Obstet Gynecol Scand 2008; 87: 319-324
    CrossrefPubMedGoogle Scholar
  • 29 Mikkelsen TB, Osterdal ML, Knudsen VK , et al. Association between a Mediterranean-type diet and risk of preterm birth among Danish women: a prospective cohort study. Acta Obstet Gynecol Scand 2008; 87: 325-330
    CrossrefPubMedGoogle Scholar
  • 30 Khoury J, Henriksen T, Christophersen B, Tonstad S. Effect of a cholesterol-lowering diet on maternal, cord, and neonatal lipids, and pregnancy outcome: a randomized clinical trial. Am J Obstet Gynecol 2005; 193: 1292-1301
    CrossrefPubMedGoogle Scholar
  • 31 Willett WC, Reynolds RD, Cottrell-Hoehner S, Sampson L, Browne ML. Validation of a semi-quantitative food frequency questionnaire: comparison with a 1-year diet record. J Am Diet Assoc 1987; 87: 43-47
    PubMedGoogle Scholar
  • 32 USDA. MyPyramid in action: tips for pregnant moms. Available at: http://www.nal.usda.gov/wicworks/Topics/pfs.pdf . Accessed October 18, 2012
    PubMedGoogle Scholar