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Synthesis 2014; 46(04): 489-495
DOI: 10.1055/s-0033-1340459
DOI: 10.1055/s-0033-1340459
paper
Povarov Reaction of β-Enamino Esters and Isatin-3-imines for Diastereoselective Synthesis of Spiro[indoline-3,2′-quinolines]
Further Information
Publication History
Received: 22 October 2013
Accepted after revision: 18 November 2013
Publication Date:
10 December 2013 (online)
Abstract
The p-toluenesulfonic acid catalyzed Povarov reaction of isatin-3-imines with β-enamino esters, which were generated in situ from the reaction of arylamines and methyl propiolate in ethanol, afforded the polysubstituted spiro[indoline-3,2′-quinolines] in high yields and with high diastereoselectivity.
Key words
Povarov reaction - hetero-Diels–Alder reaction - β-enamino ester - isatinimine - spiro[indoline-3,2′-quinolines]Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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