Synthesis 2014; 46(04): 465-474
DOI: 10.1055/s-0033-1340466
paper
© Georg Thieme Verlag Stuttgart · New York

Mild and Efficient One-Pot Synthesis of Diverse Flavanone Derivatives via an Organocatalyzed Mannich-Type Reaction

Authors

  • Srinivasu V. N. Vuppalapati

    School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea   Fax: +82(53)8104631   Email: yrlee@yu.ac.kr
  • Likai Xia

    School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea   Fax: +82(53)8104631   Email: yrlee@yu.ac.kr
  • Naushad Edayadulla

    School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea   Fax: +82(53)8104631   Email: yrlee@yu.ac.kr
  • Yong Rok Lee*

    School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea   Fax: +82(53)8104631   Email: yrlee@yu.ac.kr
Further Information

Publication History

Received: 26 October 2013

Accepted after revision: 25 November 2013

Publication Date:
16 December 2013 (online)


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Abstract

A facile ethylenediamine diacetate (EDDA)-catalyzed one-pot synthesis of biologically interesting flavanone derivatives from 2-hydroxyacetophenones, aromatic aldehydes, and aniline via a Mannich-type reaction is described. This synthetic method provides a rapid access to biologically interesting flavanone derivatives. To demonstrate this method, several biologically interesting natural products bearing a flavanone moiety were synthesized as racemates­.

Supporting Information