Synthesis, Table of Contents Synthesis 2014; 46(05): 629-634DOI: 10.1055/s-0033-1340498 paper © Georg Thieme Verlag Stuttgart · New YorkFe(Cp)2BF4: An Efficient Lewis Acid Catalyst for the Aminolysis of Epoxides Authors Author Affiliations Geeta Devi Yadav Department of Chemistry, University of Delhi, Delhi 110007, India Fax: +91(11)27666605 Email: ssingh1@chemistry.du.ac.in ManMohan Singh Chauhan Department of Chemistry, University of Delhi, Delhi 110007, India Fax: +91(11)27666605 Email: ssingh1@chemistry.du.ac.in Surendra Singh* Department of Chemistry, University of Delhi, Delhi 110007, India Fax: +91(11)27666605 Email: ssingh1@chemistry.du.ac.in Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Abstract Ferrocenium tetrafluoroborate [Fe(Cp)2BF4] is an efficient Lewis acid catalyst for the aminolysis of aromatic, aliphatic, and cyclic epoxides using aniline and substituted anilines as the nucleophile to provide regioselective β-amino alcohols in 61–97% yields under solvent-free conditions at room temperature. The ring opening of cyclohexene oxide with aliphatic amines gave 2-aminocyclohexanols in 33–98% yields at 60 °C under solvent-free conditions. Key words Key wordsepoxides - ring opening - amino alcohols - Lewis acid - Fe(Cp)2BF4 Full Text References References 1a Ager DJ, Prakash I, Schaad DR. Chem. Rev. 1996; 96: 835 1b Corey EJ, Zhang F.-Y. Angew. Chem. Int. Ed. 1999; 38: 1931 1c Johannes CW, Visser MS, Weatherhead GS, Hoveyda AH. J. Am. Chem. Soc. 1998; 120: 8340 1d Chng BL, Ganesan A. Bioorg. Med. Chem. Lett. 1997; 7: 1511 1e Alonso DA, Guijarro D, Pinho P, Temme O, Andersson PG. J. Org. Chem. 1998; 63: 2749 1f Castejon P, Moyano A, Pericas MA, Riera A. Tetrahedron 1996; 52: 7063 1g Li G, Chang H.-T, Sharpless KB. Angew. Chem. Int. Ed. 1996; 35: 451 2a Hodgson DM, Gibbs AR, Lee GP. Tetrahedron 1996; 52: 14361 2b Bergmeier SC. Tetrahedron 2000; 56: 2561 3a Deyrup JA, Moyer CL. J. Org. Chem. 1969; 34: 175 3b Freifelder M, Stone GR. J. Org. 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