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Synthesis 2014; 46(10): 1389-1398
DOI: 10.1055/s-0033-1341028
DOI: 10.1055/s-0033-1341028
paper
Efficient Catalyst-Free One-Pot Three-Component Synthesis of Novel Spirooxindole Derivatives, and Their Cytotoxic Activities
Further Information
Publication History
Received: 13 December 2013
Accepted after revision: 26 February 2014
Publication Date:
26 March 2014 (online)
Abstract
A simple and efficient one-pot approach for assembling novel spiro[indolepyranopyrrole] derivatives was developed and used to prepare a series of biologically important compounds. The reaction was easily performed with high efficiency under very simple and mild conditions without any catalysts and it gave good yields, avoiding time-consuming costly synthesis and laborious workup and purification of products. The cytotoxic activities of these new spiro[indolepyranopyrrole] derivatives were evaluated in vitro. Most of the tested compounds exhibited significant cytotoxicities to Raji cell lines.
Key words
polycyclic compounds - heterocyclic compounds - spiro compounds - multicomponent reactions - cytotoxinsSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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