Iterative Iodocyclization: Total Synthesis of Polyrhacitide B

Debendra K. Mohapatra; P. Sivarama Krishnarao; Eswar Bhimireddy; Jhillu S. Yadav

doi:10.1055/s-0033-1341154

Synthesis, Inhaltsverzeichnis

Synthesis 2014; 46(12): 1639-1647
DOI: 10.1055/s-0033-1341154

paper

Iterative Iodocyclization: Total Synthesis of Polyrhacitide B

Debendra K. Mohapatra*

Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, India Fax: +91(40)27160512 eMail: mohapatra@iict.res.in

,

P. Sivarama Krishnarao

Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, India Fax: +91(40)27160512 eMail: mohapatra@iict.res.in

,

Eswar Bhimireddy

Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, India Fax: +91(40)27160512 eMail: mohapatra@iict.res.in

,

Jhillu S. Yadav

Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, India Fax: +91(40)27160512 eMail: mohapatra@iict.res.in

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Abstract

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Abstract

A highly stereoselective total synthesis of polyrhacitide B is reported. Key reactions are an iodocyclization protocol developed in our group, the Maruoka asymmetric allylation, the Bartlett–Smith iodocarbonate cyclization, and iodolactonization.

Key words

natural products - total synthesis - iodine-catalyzed cyclization - asymmetric allylation - iodocarbonate cyclization - oxidative cleavage

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Referenzen

References and Notes
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