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Planta Med 2013; 79(14): 1341-1347
DOI: 10.1055/s-0033-1350648
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Diterpenes and Phenylpropanoids from Clerodendrum splendens

Laura Faiella
1   Dipartimento di Farmacia, Università di Pisa, Pisa, Italy
,
Abeer Temraz
2   Faculty of Pharmacy, Al Azhar University, Nasr-City, Cairo, Egypt
,
Roberta Cotugno
3   Dipartimento di Farmacia, Università di Salerno, Salerno, Italy
,
Nunziatina De Tommasi
3   Dipartimento di Farmacia, Università di Salerno, Salerno, Italy
,
Alessandra Braca
1   Dipartimento di Farmacia, Università di Pisa, Pisa, Italy
› Author Affiliations
Further Information

Publication History

received 05 May 2013
revised 12 June 2013

accepted 25 June 2013

Publication Date:
08 August 2013 (online)

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Abstract

Four new clerodane diterpenes (1–4) and one new phenylpropanoid (5) have been isolated from Clerodendrum splendens aerial parts, together with nine known compounds. Their structures were determined by spectroscopic and spectrometric analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 4 was determined by Snatzkeʼs method. Antiproliferative activity of diterpenes in HeLa cells was also evaluated. The IC50 values were 98 ± 11 µM for 3 and 101 ± 8 µM for 1, respectively.

Key words

Clerodendrum splendens - Verbenaceae - clerodane diterpenes - antiproliferative activity

Supporting Information

 

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