A New Anti-acetylcholinesterase α-Pyrone Meroterpene,
                    Arigsugacin I, from Mangrove Endophytic Fungus Penicillium sp. sk5GW1L of
                        Kandelia candel

Xishan Huang; Xuefeng Sun; Bo Ding; Ma Lin; Lan Liu; Huarong Huang; Zhigang She

doi:10.1055/s-0033-1350896

Planta Medica, Table of Contents

Planta Med 2013; 79(16): 1572-1575
DOI: 10.1055/s-0033-1350896

Natural Product Chemistry

Letters

Georg Thieme Verlag KG Stuttgart · New York

A New Anti-acetylcholinesterase α-Pyrone Meroterpene, Arigsugacin I, from Mangrove Endophytic Fungus Penicillium sp. sk5GW1L of Kandelia candel

Authors

Xishan Huang

¹School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
Xuefeng Sun

¹School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
Bo Ding

¹School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
Ma Lin

¹School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
Lan Liu

¹School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
Huarong Huang

²School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China
Zhigang She

¹School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China

Abstract

Arigsugacin I (1), a new α-pyrone meroterpene, along with two known compounds, arigsugacins F (2) and territrem B (3), were isolated from the mangrove endophytic fungus Penicillium sp. sk5GW1L from Kandelia candel. Their structures were identified through mass spectrometry and NMR experiments, and the absolute configuration of compound 1 was further confirmed by low-temperature (100 K) single crystal X-ray diffraction with Cu Kα radiation. The absolute configuration of compound 2 was first reported by using X-ray copper radiation. Compounds 1–3 showed inhibitory activities against acetylcholinesterase with IC₅₀ values of 0.64 ± 0.08 µM, 0.37 ± 0.11 µM, and 7.03 ± 0.20 nM, respectively.

Key words

arigsugacin - territrem - Kandelia candel - Rhizophoraceae - Penicillium sp. fungus

Full Text

References

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