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Planta Med 2013; 79(16): 1572-1575
DOI: 10.1055/s-0033-1350896
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

A New Anti-acetylcholinesterase α-Pyrone Meroterpene, Arigsugacin I, from Mangrove Endophytic Fungus Penicillium sp. sk5GW1L of Kandelia candel

Xishan Huang
1   School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
,
Xuefeng Sun
1   School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
,
Bo Ding
1   School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
,
Ma Lin
1   School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
,
Lan Liu
1   School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
,
Huarong Huang
2   School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China
,
Zhigang She
1   School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
› Author Affiliations
Further Information

Publication History

received 07 April 2013
revised 13 August 2013

accepted 19 August 2013

Publication Date:
30 September 2013 (online)

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Abstract

Arigsugacin I (1), a new α-pyrone meroterpene, along with two known compounds, arigsugacins F (2) and territrem B (3), were isolated from the mangrove endophytic fungus Penicillium sp. sk5GW1L from Kandelia candel. Their structures were identified through mass spectrometry and NMR experiments, and the absolute configuration of compound 1 was further confirmed by low-temperature (100 K) single crystal X-ray diffraction with Cu Kα radiation. The absolute configuration of compound 2 was first reported by using X-ray copper radiation. Compounds 1–3 showed inhibitory activities against acetylcholinesterase with IC50 values of 0.64 ± 0.08 µM, 0.37 ± 0.11 µM, and 7.03 ± 0.20 nM, respectively.

Key words

arigsugacin - territrem - Kandelia candel - Rhizophoraceae - Penicillium sp. fungus

Supporting Information

 

  • References

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