Planta Med 2014; 80(04): 315-320
DOI: 10.1055/s-0033-1360363
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Fatsioside A, a Rare Baccharane-Type Glycoside Inhibiting the Growth of Glioma Cells from the Fruits of Fatsia japonica

Siran Yu
1   Ocean College, Zhejiang University, Hangzhou, China
,
Xuewei Ye
1   Ocean College, Zhejiang University, Hangzhou, China
,
Wenxiu Xin
2   College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
,
Kangning Xu
2   College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
,
Xiao-Yuan Lian
2   College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
,
Zhizhen Zhang
1   Ocean College, Zhejiang University, Hangzhou, China
› Author Affiliations
Further Information

Publication History

received 29 September 2013
revised 03 January 2014

accepted 20 January 2014

Publication Date:
18 February 2014 (online)

Abstract

A novel baccharane-type triterpenoid glycoside named fatsioside A (1), together with ten oleanane glycosides, were isolated from the fruits of Fatsia japonica. The structure of fatsioside A was assigned as 3β,15α,18α-trihydroxy-18,19-secolupane-12,19-dione 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside by extensive NMR and HRESIMS analyses. F. japonica is the third baccharane glycoside-containing species reported to date in the plant kingdom, while fatsioside A represents the first baccharane glycoside found in the Araliaceae family. Fatsioside A inhibited the growth of rat glioma C6 cells and human glioma U251 cells with IC50 values of 33.48 ± 2.01 µM and 77.58 ± 6.19 µM, respectively. Further investigation indicated that fatsioside A induced apoptosis and necrosis in glioma cells, and arrested the cell cycle at the G0/G1 phase.

Supporting Information

 
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