Novel and Efficient Debenzylation of N-Benzyltetrazole Derivatives with the Rosenmund Catalyst

Abstract

The Rosenmund catalyst (Pd/BaSO₄) was found to efficiently catalyze debenzylation of N-benzyltetrazole derivatives with ammonium formate by catalytic transfer hydrogenation under mild conditions. The protocol has been applied to functionalized substrates to provide various angiotensin II receptor blockers in excellent yields.

Key words

palladium - cleavage - hydrogen transfer - heterocycles - protecting groups

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