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Synthesis 2015; 47(19): 3067-3078
DOI: 10.1055/s-0034-1378845
DOI: 10.1055/s-0034-1378845
paper
An Efficient Route to N-Monosubstituted Guanidino-Lactams
Autoren
Weitere Informationen
Publikationsverlauf
Received: 15. Februar 2015
Accepted after revision: 05. Juni 2015
Publikationsdatum:
25. Juni 2015 (online)
Abstract
A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.
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