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Synthesis 2015; 47(10): 1399-1404
DOI: 10.1055/s-0034-1380137
DOI: 10.1055/s-0034-1380137
paper
A Novel Asymmetric Synthesis of (+)-Deoxytylophorinine
Further Information
Publication History
Received: 10 October 2014
Accepted after revision: 09 January 2015
Publication Date:
04 March 2015 (online)
Abstract
A novel asymmetric synthesis of a phenanthroindolizidine alkaloid, (+)-deoxytylophorinine, is reported, which uses a chiral nickel(II) complex of a glycine Schiff base to synthesize a substituted (R)-3-phenanthrylalanine as a key intermediate and Meldrum’s acid to construct the E ring.
Key words
phenanthroindolizidine alkaloids - (+)-deoxytylophorinine - asymmetric synthesis - anticancer agents - non-proteinogenic α-amino acidsSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380137.
- Supporting Information
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