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Eur J Pediatr Surg 2014; 24(03): 237-245
DOI: 10.1055/s-0034-1382260
Review
Georg Thieme Verlag KG Stuttgart · New York

In Utero Stem Cell and Gene Therapy: Current Status and Future Perspectives

Stavros P. Loukogeorgakis
1   Surgery Unit, University College London Institute of Child Health, London, United Kingdom
,
Alan W. Flake
2   The Children's Hospital of Philadelphia, and The University of Pennsylvania School of Medicine - The Center for Fetal Diagnosis and Treatment, Philadelphia, Pennsylvania, United States
› Author Affiliations
Further Information

Publication History

05 May 2014

07 May 2014

Publication Date:
19 June 2014 (online)

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Abstract

Advances in prenatal diagnosis have led to the development of fetal therapies for congenital disorders. Although in utero surgical intervention has been used successfully for correction of anatomical defects that cause fetal demise or long-term disability, its clinical indications remain limited. In contrast, prenatal stem cell and gene therapy might have tremendous potential to treat multiple inherited disorders, and could dramatically expand the use of fetal intervention to a wide range of anticipated pediatric and adult diseases. Despite encouraging results from studies in animal models of disease, the clinical utility of such therapies has been restricted by poor efficacy and concerns about safety. The aim of this review is to summarize experimental progress toward clinical application of in utero stem cell transplantation and gene transfer for the treatment of congenital disease.

Keywords

prenatal treatment - fetal therapy - stem cell transplantation - gene therapy
 

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