Isolation and Cytotoxic Effect of Anthraquinones from Morinda umbellata

Abstract

Four new anthraquinones, 1,6-dihydroxy-2-methoxymethylanthraquinone (1), 6-hydroxy-7-methoxy-2-methoxymethylanthraquinone (3), 3,6-dihydroxy-7-methoxy-2-methylanthraquinone (4), and 6-hydroxy-2-methoxymethylanthraquinone (8), together with 12 known anthraquinones and 6 other known compounds, were isolated from the EtOAc extract of Morinda umbellata. Among the isolated compounds, 1, rubiadin (14), and, 3-hydroxy-2-hydroxymethylanthraquinone (16) exhibited significant cytotoxicities against HepG2 cells, with GI₅₀ values of 4.4, 3.6, and 4.8 µM, respectively.

Key words

Morinda umbellate - Rubiaceae - 1,6-dihydroxy-2-methoxymethyl-anthraquinone - 6-hydroxy-7-methoxy-2-methoxymethylanthraquinone - 3,6-dihydroxy-7-methoxy-2-methylanthraquinone - 6-hydroxy-2-methoxymethylanthraquinone - cytotoxicity

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