Paraneoplastic Vitelliform Retinopathy Secondary to Metastatic Melanoma

Background

Traditionally, the paraneoplastic retinopathies have been classified into two entities: CAR (carcinoma-associated retinopathy) and MAR (melanoma-associated retinopathy). Recently, a vitelliform retinopathy has been described in both metastatic cancer and melanoma patients: in 2001, Borkowksi reported the first patient as a case of MAR with unusual retinal features [1]. Since then, only 20 cases have been reported [2], [3], [4], [5]. This auto-immune disorder is caused by circulating autoantibodies, cross-reacting with the neuroretina and retinal pigment epithelium (RPE) [2].

• References

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