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Ruthenium-Catalyzed Asymmetric Yne–Enone Cyclizations
Chiral Cationic CpXRu(II) Complexes for Enantioselective Yne–Enone Cyclizations.
J. Am. Chem. Soc. 2015;
17 November 2015 (online)
The authors report asymmetric yne–enone cyclizations catalyzed by chiral cationic CpXRuII complexes. A variety of 4H-pyrans were obtained in good yields (≤95%) and high enantioselectivities (er ≤ 99:1).
A new class of chiral CpXRuII complexes was synthesized that provide opportunities for the development of synthetically valuable enantioselective transformations.