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Synfacts 2015; 11(12): 1275
DOI: 10.1055/s-0035-1560930
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ruthenium-Catalyzed Asymmetric Yne–Enone Cyclizations

Contributor(s):
Hisashi Yamamoto
,
Masahiro Sai
Kossler D, Cramer N * Ècole Polytechnique Fédérale de Lausanne, Switzerland
Chiral Cationic CpXRu(II) Complexes for Enantioselective Yne–Enone Cyclizations.

J. Am. Chem. Soc. 2015;
137: 12478-12481
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Further Information

Publication History

Publication Date:
17 November 2015 (online)

 
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Key words

asymmetric catalysis - ligands - cyclization - alkynes - enones - ruthenium

Significance

The authors report asymmetric yne–enone cyclizations catalyzed by chiral cationic CpXRuII complexes. A variety of 4H-pyrans were obtained in good yields (≤95%) and high enantio­selectivities (er ≤ 99:1).


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Comment

A new class of chiral CpXRuII complexes was synthesized that provide opportunities for the development of synthetically valuable enantio­selective transformations.


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