Continuous Flow Synthesis of Dimethylalkynylaluminum Reagents

In memory of Prof. Jean Normant

Abstract

A new process for the synthesis of dimethylalkynylaluminum reagents under flow conditions is described. It involves a base-catalyzed alumination of terminal alkynes using a resin-supported organocatalyst. Final organometallic species are obtained in solution, and can further react with various aldehydes or nitrones.

Key words

organoaluminum - flow chemistry - metalation - alkynes - trimethylaluminum

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