Aluminum Chloride Mediated Reactions of N-Alkylated Tosyl­hydrazones and Terminal Alkynes: A Regioselective Approach to 1,3,5-Trisubstituted Pyrazoles

Meng Tang; Yun Wang; Hu Wang; Yuanfang Kong

doi:10.1055/s-0035-1561646

Synthesis, Inhaltsverzeichnis

Synthesis 2016; 48(18): 3065-3076
DOI: 10.1055/s-0035-1561646

paper

Aluminum Chloride Mediated Reactions of N-Alkylated Tosylhydrazones and Terminal Alkynes: A Regioselective Approach to 1,3,5-Trisubstituted Pyrazoles

Autoren

Meng Tang*

School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. of China eMail: tangmeng@lzu.edu.cn
Yun Wang

School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. of China eMail: tangmeng@lzu.edu.cn
Hu Wang

School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. of China eMail: tangmeng@lzu.edu.cn
Yuanfang Kong

School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. of China eMail: tangmeng@lzu.edu.cn

Abstract

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Abstract

Aluminum chloride mediated reactions of N-alkylated tosylhydrazones and terminal alkynes are reported. The protocol is applied to a wide range of substrates, and demonstrates excellent functional group tolerance. A series of 1,3,5-trisubstituted pyrazoles is prepared in good to high yields with complete regioselectivity.

Key words

aluminum chloride - tosylhydrazones - alkynes - pyrazoles - regioselectivity

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Referenzen

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Zusatzmaterial

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Aluminum Chloride Mediated Reactions of N-Alkylated Tosyl­hydrazones and Terminal Alkynes: A Regioselective Approach to 1,3,5-Trisubstituted Pyrazoles

Autoren

Aluminum Chloride Mediated Reactions of N-Alkylated Tosylhydrazones and Terminal Alkynes: A Regioselective Approach to 1,3,5-Trisubstituted Pyrazoles