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Direct Cross-Couplings of Propargylic Diols
Direct Cross-Couplings of Propargylic Diols.
Angew. Chem. Int. Ed. 2016;
18 August 2016 (online)
The authors report a step-economical and functional group tolerant method for the synthesis of tetra-, penta-, and hexa-substituted 1,3-butadienes from underivatized propargylic diols and aryl or alkenyl boronic acids in moderate to high yields.
The reported method can be applied to remarkably short syntheses of highly substituted benzofulvenes and aryl indenes through treatment of the cross-coupled products with acid.