Iron(III) Chloride/l-Proline as an Efficient Catalyst for the Synthesis of 3-Substituted 1,2,4-Oxadiazoles from Amidoximes and Triethyl Orthoformate

Babak Kaboudin; Foad Kazemi; Maryam Pirouz; Aysan Baharian Khoshkhoo; Jun-ya Kato; Tsutomu Yokomatsu

doi:10.1055/s-0035-1562431

Synthesis, Inhaltsverzeichnis

Synthesis 2016; 48(20): 3597-3602
DOI: 10.1055/s-0035-1562431

paper

Iron(III) Chloride/l-Proline as an Efficient Catalyst for the Synthesis of 3-Substituted 1,2,4-Oxadiazoles from Amidoximes and Triethyl Orthoformate

Autoren

Babak Kaboudin*

^aDepartment of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran eMail: kaboudin@iasbs.ac.ir
Foad Kazemi

^aDepartment of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran eMail: kaboudin@iasbs.ac.ir
Maryam Pirouz

^aDepartment of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran eMail: kaboudin@iasbs.ac.ir
Aysan Baharian Khoshkhoo

^aDepartment of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran eMail: kaboudin@iasbs.ac.ir
Jun-ya Kato

^bSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Tsutomu Yokomatsu

^bSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

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Abstract

A general, facile, and efficient method is presented for the synthesis of 3-substituted 1,2,4-oxadiazoles from amidoximes and triethyl orthoformate. The procedure employs an iron(III) chloride/l-proline catalytic system and the 3-substituted 1,2,4-oxadiazole products are obtained in moderate to good yields.

Key words

1,2,4-oxadiazoles - iron(III) chloride - l-proline - amidoximes - triethyl orthoformate

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Referenzen

References

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