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Synthesis 2017; 49(18): 4341-4349
DOI: 10.1055/s-0036-1590803
DOI: 10.1055/s-0036-1590803
paper
An Efficient Cascade Synthesis of Ethyl 3-Amino-5-oxoisoxazolidine-4-carboxylate Derivatives
We are grateful for financial support from the National Natural Science Foundation of China (No. 81673287).Further Information
Publication History
Received: 01 April 2017
Accepted after revision: 25 May 2017
Publication Date:
11 July 2017 (online)
Abstract
An efficient cascade synthesis of ethyl 3-amino-5-oxoisoxazolidine-4-carboxylate derivatives from diethyl 2-(ethoxymethylene)malonate, different hydroxylamines and various amines is developed. This approach tolerates a wide range of amines affording highly functionalized isoxazolidine derivatives, which are expected to be important in organic synthesis and medicinal chemistry.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590803.
- Supporting Information
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