Highly Selective Approach to α-Iodoketones from Aminoalkynols with Iodine Monochloride

Abstract

A protocol has been developed to achieve selective and direct synthesis of α-iodoketones under mild condition, from the reaction of aminoalkynols with iodine monochloride. The scope of the reaction was investigated using various aminoalkynols with iodine monochloride and the corresponding α-iodoketones were obtained selectively without forming iodocyclized and/or addition products.

Key words

iodine monochloride - regioselective - iodonium activation - α-iodoketones - iodocyclization

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