Enantioselective Functionalization of Internal Alkenes
Catalytic Allylic Oxidation of Internal Alkenes to a Multifunctional Chiral Building Block.
18 September 2017 (online)
The authors developed an enantioselective introduction of electrophilic oxidants into internal alkenes by using a hetero-ene reaction. A Lewis-acid-assisted Brønsted-acid system enables this transformation with high selectivity.
The utility of this transformation was demonstrated by the derivatization of the products to give various valuable chiral compounds. A reaction mechanism is proposed on the basis of mechanistic experiments.