Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596898
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

β-secretase inhibitors from sesame seeds and turmeric rhizomes

Authors

  • K Murata

    1   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, 3 – 4-1 Kowakae, 577 – 8502 Higashiosaka, Japan

  • S Matsumura

    2   INABATA KORYO CO., LTD., 3 – 5-20 Tagawa, Yodogawaku, 532 – 0027 Osaka, Japan

  • Y Yoshioka

    2   INABATA KORYO CO., LTD., 3 – 5-20 Tagawa, Yodogawaku, 532 – 0027 Osaka, Japan

  • N Zaima

    3   Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, 3327 – 204 Nakamachi, 631 – 8505 Nara, Japan

  • M Morimoto

    3   Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, 3327 – 204 Nakamachi, 631 – 8505 Nara, Japan

  • H Matsuda

    1   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, 3 – 4-1 Kowakae, 577 – 8502 Higashiosaka, Japan
Further Information

Publication History

Publication Date:
14 December 2016 (online)

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    In the research program for exploring effective plant material for dementia, authors found that the extracts from spices and herbs used mainly in Asian countries possess β-secretase. Firstly, we focused on curry spices, which are inspired by the low numbers of dementia patients in Asian countries [1]. Among the samples tested, ethyl acetate extracts of turmeric rhizome, black pepper fruit and curry leaf showed potent inhibitory activities on β-secretase [2]. In our extended studies, hexane extract of turmeric (rhizome) and ethyl acetate extract of sesame (seed) possessed relatively high inhibitory activities as 82.5% and 39.0% of inhibitions at 250 µg/mL, respectively [3]. The active principles were disclosed as turmerones and sesamins (indicated in figure below). Curcuminoids from turmeric (rhizome) have been reported to possess inhibitory activities on β-secretase, while more low polar compounds, turmerones, showed more potent activity. Sesamin has known as one of the effective functional ingredients in Japan. However, we found that sesamolin would be a more useful ingredient in β-secretase inhibition. Preliminary absorption experiments were also conducted in order to demonstrate the transition of these compounds to brain in intact form at reasonable levels. As results, 30 mg/head oral administration to mice led to the detection of α-turmerone, β-turmerone and ar- turmerone in cerebrum at 362, 640 and 117 ng/g, respectively. On the other hand, 50 mg/head oral administration of sesamin and sesamolin to mice led to detect in cerebrum at 54 and 305 ng/g, respectively. From these results, turmeric and sesame may have played an important role as agents for prevention of dementia in daily consumption.

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    Keywords: Dementia, β-secretase, acetylcholinesterase, sesame, turmeric.

    References:

    [1] Chandra V, Pandav R, Dodge HH, Johnston JM, Belle SH, DeKosky ST, Ganguli M. Incidence of Alzheimer's disease in a rural community in India. Neurology 2001; 57: 985 – 989

    [2] Murata K, Matsumura S, Yoshioka Y, Ueno Y, Matsuda H. Screening of β-secretase and acetylcholinesterase inhibitors from plant resources. J Nat Med 2015; 69: 123 – 129

    [3] Matsumura S, Murata K, Yoshioka Y, Matsuda H. Search for β-secretase inhibitors from natural spices. Nat Prod Comm 2016; 11: 507 – 510


     

    No conflict of interest has been declared by the author(s).

     
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