Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596964
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

In vitro and in vivo antiplasmodial activity of Colombian plants against human malaria Plasmodium falciparum

Autoren

  • SM Robledo

    1   PECET, IIM, School of Medicine, University of Antioquia. Carrera 53 # 61 – 30. Zip code 0500100. Medellin-Colombia

  • Y Upegui

    1   PECET, IIM, School of Medicine, University of Antioquia. Carrera 53 # 61 – 30. Zip code 0500100. Medellin-Colombia
    2   Animal Patology Laboratory, Veterinary School, University of Antioquia. Zip code 0500100. Medellin-Colombia

  • J Murillo

    2   Animal Patology Laboratory, Veterinary School, University of Antioquia. Zip code 0500100. Medellin-Colombia

  • B Rodriguez

    2   Animal Patology Laboratory, Veterinary School, University of Antioquia. Zip code 0500100. Medellin-Colombia

  • LE Cuca

    2   Animal Patology Laboratory, Veterinary School, University of Antioquia. Zip code 0500100. Medellin-Colombia
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Publikationsverlauf

Publikationsdatum:
14. Dezember 2016 (online)

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Despite government efforts, malaria remains a major public health problem worldwide with high rates of morbi-mortality due to limited treatment options and emergence of drug resistance and new endemic areas. The validation of traditional use of plants constitutes an interesting strategy to discover and develop new and better drugs. In this study, 25 plant extracts belonging to families Lauraceae, Myristiacea, Rutaceae and Gentianaceae were tested on asynchronic cultures of Plasmodium falciparum by determining the antiplasmodial effect using fluorometric quantitation of parasite DNA. The therapeutic efficacy in Balb/C mice infected with P. berghei was also studied. Ethanol extracts of Zanthoxylum fagara, Raputia heptaphylla and Esenbeckia alata leaves showed IC50 < 20 µg/ml respectively, suggesting their antiplasmodial potential. Moreover, the best activity was showed by the Rutaceae family extracts although they also showed some hemolytic activity. The better therapeutic response in mice was observed for ethanol extract of E. alata with 66.3% reduction in parasitemia on the third day after intraperitoneal administration, while R. heptaphylla showed no decrease in parasitemia. These results provide important basis to suggest that E. alata has potential to be considered as an alternative therapy for malaria. Therefore, it is necessary to continue studies to confirm its usefulness in the treatment of malaria.

Acknowledgements: Universidad Nacional de Colombia (Bogotá, Colombia) and CIDEPRO Institute (Medellín, Colombia).

Keywords: Malaria, traditional medicine, antimalarial plants, Plasmodium berghei, Plasmodium falciparum.

References:

[1] Lawal B, Shittu OK, Kabiru AY, Jigam AA, Umar MB, Berinyuy EB, Alozieuwa BUJ. Potential antimalarials from African natural products: A review. Intercult Ethnopharmacol 2015; 4: 318 – 343.

[2] Chinsembu KC. Plants as antimalarial agents in Sub-Saharan Africa. Acta Trop 2015; 152: 32 – 48.


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