Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1597067
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Anti-inflammatory activity of 3 kinds of Salvia and its active compounds

HJ Shin
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
,
M Jang
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
,
SH Park
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
,
HJ Min
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
,
JM Lee
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
,
MY Lee
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
,
SH Lee
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
,
SW Kim
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
,
CK Han
1   KT&G Research Institute Daejeon, 305 – 805 South Korea
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

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    Salvia has been widely cultivated for using in flavouring and folk medicines in many countries, including Korea and China. In this study, we investigated the effect of Salvia extract and its fractions on anti-inflammatory activity and the underlying active compounds. Anti-inflammation activity was measured by the inhibitory effect of cysteinyl leukotriene production with basophilic leukemia (RBL)-2H3 mast cell. Salvia plebeia R. Br was found to have the most potent inhibitory activity of leukotriene production comparing to Salvia japonica and Salvia chanroenica. Ethylacetate (EtOAc) fraction from the 50% ethanol extract of Salvia plebeia exhibited more strong anti-inflammation activity than that of other solvent fractions. The major components of leukotriene production inhibition activity were isolated from EtOAc extract by silica gel column chromatography. These results suggest that rosmarinic acid, hispidulin and luteolin were identified as major compounds showing anti-inflammatory effect of Salvia plebeia.

    Acknowledgements: This work was supported by the IPET grand funded by Korea Institute of Planning & Evaluation for Technology in Food, Agriculture, Forestry & fisheries.

    Keywords: Salvia, anti-inflammation activity, leukotriene, rosmarinic acid, hispidulin, luteolin.

    References:

    [1] Choi JK, Oh HM, Park JH, Choi JH, Sa KH, Kang YM, Park PH, Shin TY, Rho MC, Kim SH. Salvia plebeia extract inhibits the inflammatory response in human rheumatoid synovial fibroblasts and a murine model of arthritis. Phytomedicine 2015; 22: 415 – 422.

    [2] Nugroho A, Kim MH, Choi J, Baek NI, Park HJ. In vivo sedative and gastroprotective activities of Salvia plebeia extract and its composition of polyphenol. Arch Pharm Res 2012; 35: 1403 – 1411.

    [3] Jung HJ, Song YS, Lim CJ, Park EH. Anti-inflammatory, anti-angiogenic and anti-nocieptive activities of an ethanol extract of Salvia plebeia R Brown. J Ethnopharmacol 2009; 126: 355 – 360.


     

    No conflict of interest has been declared by the author(s).