Am J Perinatol 2018; 35(04): 324-330
DOI: 10.1055/s-0037-1608630
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A Practical Approach to Neonatal Opiate Withdrawal Syndrome

Lori A. Devlin
1   Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky
,
Jonathan M. Davis
2   Department of Pediatrics, The Floating Hospital at Tufts Medical Center and the Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts
› Author Affiliations
Further Information

Publication History

29 September 2017

29 September 2017

Publication Date:
03 November 2017 (online)

Abstract

Perinatal opioid misuse and neonatal opioid withdrawal syndrome (NOWS) are a significant public health problem that has grown exponentially over the past decade. In the United States, a woman seeks emergency room care for prescription opioid misuse every 3 minutes and approximately every 25 minutes, a child is born with signs of drug withdrawal. The economic impact of perinatal opioid misuse is significant with annual hospital charges for NOWS in 2012 as $1.5 billion dollars. Perinatal opioid misuse is a complex, multifaceted problem that demands a multidisciplinary cross specialty approach. This article will review the current state of NOWS and provide medical practitioners with a practical guide to enhance evidence based practice.

 
  • References

  • 1 Centers for Disease Control and Prevention. Vital signs: prescription painkiller overdoses: a growing epidemic, especially among women. 2016 . Available at: http://www.cdc.gov/vitalsigns/prescriptionpainkilleroverdoses/ . Accessed September 25, 2017
  • 2 International Narcotics Control Board. Report of the International Narcotics Control Board for 2010. Available at: https://www.incb.org/documents/Publications/AnnualReports/AR2010/AR_2010_English.pdf . Accessed September 25, 2017
  • 3 Paulozzi LJ, Mack KA, Hockenberry JM. ; Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC. Vital signs: variation among States in prescribing of opioid pain relievers and benzodiazepines - United States, 2012. Morb Mortal Wkly Rep 2014; 63 (26) 563-568
  • 4 Ailes EC, Dawson AL, Lind JN. , et al; Centers for Disease Control and Prevention (CDC). Opioid prescription claims among women of reproductive age--United States, 2008-2012. Morb Mortal Wkly Rep 2015; 64 (02) 37-41
  • 5 O'Donnell JK, Gladden RM, Seth P. Trends in deaths involving heroin and synthetic opioids excluding methadone, and law enforcement drug product reports, by census region - United States, 2006-2015. Morb Mortal Wkly Rep 2017; 66 (34) 897-903
  • 6 Frank RG, Pollack HA. Addressing the fentanyl threat to public health. N Engl J Med 2017; 376 (07) 605-607
  • 7 Patrick SW, Davis MM, Lehman CU, Cooper WO. Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012. J Perinatol 2015; 35 (08) 667
  • 8 Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009. JAMA 2012; 307 (18) 1934-1940
  • 9 Tolia VN, Patrick SW, Bennett MM. , et al. Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs. N Engl J Med 2015; 372 (22) 2118-2126
  • 10 Campa D, Gioia A, Tomei A, Poli P, Barale R. Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther 2008; 83 (04) 559-566
  • 11 Schuckit MA. Treatment of opioid-use disorders. N Engl J Med 2016; 375 (04) 357-368
  • 12 Committee opinion no. 633: alcohol abuse and other substance use disorders: ethical issues in obstetric and gynecologic practice. Obstet Gynecol 2015; 125 (06) 1529-1537
  • 13 El-Mohandes A, Herman AA, Nabil El-Khorazaty M, Katta PS, White D, Grylack L. Prenatal care reduces the impact of illicit drug use on perinatal outcomes. J Perinatol 2003; 23 (05) 354-360
  • 14 ACOG Committee on Health Care for Underserved Women; American Society of Addiction Medicine. ACOG Committee Opinion No. 524: opioid abuse, dependence, and addiction in pregnancy. Obstet Gynecol 2012; 119 (05) 1070-1076
  • 15 Reddy UM, Davis JM, Ren Z, Greene MF. ; Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes Workshop Invited Speakers. Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes: executive summary of a joint workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, American Academy of Pediatrics, Society for Maternal-Fetal Medicine, Centers for Disease Control and Prevention, and the March of Dimes Foundation. Obstet Gynecol 2017; 130 (01) 10-28
  • 16 Wolff K, Farrell M, Marsden J. , et al. A review of biological indicators of illicit drug use, practical considerations and clinical usefulness. Addiction 1999; 94 (09) 1279-1298
  • 17 Strano-Rossi S. Methods used to detect drug abuse in pregnancy: a brief review. Drug Alcohol Depend 1999; 53 (03) 257-271
  • 18 Yonkers KA, Howell HB, Gotman N, Rounsaville BJ. Self-report of illicit substance use versus urine toxicology results from at-risk pregnant women. J Subst Use 2011; 16 (05) 372-389
  • 19 Concheiro M, González-Colmenero E, Lendoiro E. , et al. Alternative matrices for cocaine, heroin, and methadone in utero drug exposure detection. Ther Drug Monit 2013; 35 (04) 502-509
  • 20 Terplan M, McNamara EJ, Chisolm MS. Pregnant and non-pregnant women with substance use disorders: the gap between treatment need and receipt. J Addict Dis 2012; 31 (04) 342-349
  • 21 Terplan M, Longinaker N, Appel L. Women-centered drug treatment services and need in the United States, 2002-2009. Am J Public Health 2015; 105 (11) e50-e54
  • 22 Kennare R, Heard A, Chan A. Substance use during pregnancy: risk factors and obstetric and perinatal outcomes in South Australia. Aust N Z J Obstet Gynaecol 2005; 45 (03) 220-225
  • 23 Albright B, de la Torre L, Skipper B, Price S, Abbott P, Rayburn W. Changes in methadone maintenance therapy during and after pregnancy. J Subst Abuse Treat 2011; 41 (04) 347-353
  • 24 Shiu JR, Ensom MH. Dosing and monitoring of methadone in pregnancy: literature review. Can J Hosp Pharm 2012; 65 (05) 380-386
  • 25 Jansson LM, Dipietro JA, Velez M, Elko A, Knauer H, Kivlighan KT. Maternal methadone dosing schedule and fetal neurobehaviour. J Matern Fetal Neonatal Med 2009; 22 (01) 29-35
  • 26 Wiegand SL, Stringer EM, Stuebe AM, Jones H, Seashore C, Thorp J. Buprenorphine and naloxone compared with methadone treatment in pregnancy. Obstet Gynecol 2015; 125 (02) 363-368
  • 27 Center for Substance Abuse Treatment. Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Rockville, MD: SAMHSA; 2004
  • 28 Walsh SL, Preston KL, Stitzer ML, Cone EJ, Bigelow GE. Clinical pharmacology of buprenorphine: ceiling effects at high doses. Clin Pharmacol Ther 1994; 55 (05) 569-580
  • 29 Bell JR, Butler B, Lawrance A, Batey R, Salmelainen P. Comparing overdose mortality associated with methadone and buprenorphine treatment. Drug Alcohol Depend 2009; 104 (1-2): 73-77
  • 30 Jones HE, Heil SH, Baewert A. , et al. Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review. Addiction 2012; 107 (Suppl. 01) 5-27
  • 31 Jones HE, Kaltenbach K, Heil SH. , et al. Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med 2010; 363 (24) 2320-2331
  • 32 Johnson RE, Jones HE, Fischer G. Use of buprenorphine in pregnancy: patient management and effects on the neonate. Drug Alcohol Depend 2003; 70 (2, Suppl): S87-S101
  • 33 Minozzi S, Amato L, Bellisario C, Ferri M, Davoli M. Maintenance agonist treatments for opiate-dependent pregnant women. Cochrane Database Syst Rev 2013; (12) CD006318
  • 34 Kraft WK, Stover MW, Davis JM. Neonatal abstinence syndrome: pharmacologic strategies for the mother and infant. Semin Perinatol 2016; 40 (03) 203-212
  • 35 Huybrechts KF, Bateman BT, Desai RJ. , et al. Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study. BMJ 2017; 358: j3326
  • 36 Dryden C, Young D, Hepburn M, Mactier H. Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. BJOG 2009; 116 (05) 665-671
  • 37 Jansson LM, Di Pietro JA, Elko A, Williams EL, Milio L, Velez M. Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes. Drug Alcohol Depend 2012; 122 (03) 213-219
  • 38 Wachman EM, Newby PK, Vreeland J. , et al. The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome. J Addict Med 2011; 5 (04) 293-299
  • 39 Kaltenbach K, Holbrook AM, Coyle MG. , et al. Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication. Addiction 2012; 107 (Suppl. 01) 45-52
  • 40 Kendler KS, Karkowski LM, Neale MC, Prescott CA. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch Gen Psychiatry 2000; 57 (03) 261-269
  • 41 Mague SD, Blendy JA. OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. Drug Alcohol Depend 2010; 108 (03) 172-182
  • 42 Goldman D, Oroszi G, Ducci F. The genetics of addictions: uncovering the genes. Nat Rev Genet 2005; 6 (07) 521-532
  • 43 Wachman EM, Hayes MJ, Brown MS. , et al. Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. JAMA 2013; 309 (17) 1821-1827
  • 44 Wachman EM, Hayes MJ, Sherva R. , et al. Variations in opioid receptor genes in neonatal abstinence syndrome. Drug Alcohol Depend 2015; 155: 253-259
  • 45 Wachman EM, Hayes MJ, Lester BM. , et al. Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome. J Pediatr 2014; 165 (03) 472-478
  • 46 Hudak ML, Tan RC. ; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics. Neonatal drug withdrawal. Pediatrics 2012; 129 (02) e540-e560
  • 47 Bagley SM, Wachman EM, Holland E, Brogly SB. Review of the assessment and management of neonatal abstinence syndrome. Addict Sci Clin Pract 2014; 9 (01) 19
  • 48 Finnegan LP, Connaughton Jr JF, Kron RE, Emich JP. Neonatal abstinence syndrome: assessment and management. Addict Dis 1975; 2 (1-2): 141-158
  • 49 Lipsitz PJ. A proposed narcotic withdrawal score for use with newborn infants. A pragmatic evaluation of its efficacy. Clin Pediatr (Phila) 1975; 14 (06) 592-594
  • 50 Zahorodny W, Rom C, Whitney W. , et al. The neonatal withdrawal inventory: a simplified score of newborn withdrawal. J Dev Behav Pediatr 1998; 19 (02) 89-93
  • 51 Green M, Suffet F. The Neonatal Narcotic Withdrawal Index: a device for the improvement of care in the abstinence syndrome. Am J Drug Alcohol Abuse 1981; 8 (02) 203-213
  • 52 Ostrea Jr EM, Chavez CJ, Strauss ME. A study of factors that influence the severity of neonatal narcotic withdrawal. Addict Dis 1975; 2 (1-2): 187-199
  • 53 Jansson LM, Velez M, Harrow C. The opioid-exposed newborn: assessment and pharmacologic management. J Opioid Manag 2009; 5 (01) 47-55
  • 54 O'Grady MJ, Hopewell J, White MJ. Management of neonatal abstinence syndrome: a national survey and review of practice. Arch Dis Child Fetal Neonatal Ed 2009; 94 (04) F249-F252
  • 55 Micard S, Brion F. [Management of the opioid withdrawal in the neonates: French and European survey]. Arch Pediatr 2003; 10 (03) 199-203
  • 56 Sarkar S, Donn SM. Management of neonatal abstinence syndrome in neonatal intensive care units: a national survey. J Perinatol 2006; 26 (01) 15-17
  • 57 Mehta A, Forbes KD, Kuppala VS. Neonatal abstinence syndrome management from prenatal counseling to postdischarge follow-up care: results of a national survey. Hosp Pediatr 2013; 3 (04) 317-323
  • 58 Finnegan LP, Kron RE, Connaughton JF, Emich JP. Assessment and treatment of abstinence in the infant of the drug-dependent mother. Int J Clin Pharmacol Biopharm 1975; 12 (1-2): 19-32
  • 59 Zimmermann-Baer U, Nötzli U, Rentsch K, Bucher HU. Finnegan neonatal abstinence scoring system: normal values for first 3 days and weeks 5-6 in non-addicted infants. Addiction 2010; 105 (03) 524-528
  • 60 Maguire D, Cline GJ, Parnell L, Tai CY. Validation of the Finnegan neonatal abstinence syndrome tool-short form. Adv Neonatal Care 2013; 13 (06) 430-437
  • 61 Gomez Pomar E, Finnegan LP, Devlin L. , et al; Retrospective Study of Two Institutions in the US. Simplification of the Finnegan Neonatal Abstinence Scoring System: retrospective study of two institutions in the USA. BMJ Open 2017; 7 (09) e016176
  • 62 Grossman MR, Berkwitt AK, Osborn RR. , et al. An initiative to improve the quality of care of infants with neonatal abstinence syndrome. Pediatrics 2017; 139 (06) e20163360
  • 63 Patrick SW, Schumacher RE, Horbar JD. , et al. Improving care for neonatal abstinence syndrome. Pediatrics 2016; 137 (05) e20153835
  • 64 Velez M, Jansson LM. The opioid dependent mother and newborn dyad: non-pharmacologic care. J Addict Med 2008; 2 (03) 113-120
  • 65 Velez ML, Jansson LM, Schroeder J, Williams E. Prenatal methadone exposure and neonatal neurobehavioral functioning. Pediatr Res 2009; 66 (06) 704-709
  • 66 Abdel-Latif ME, Pinner J, Clews S, Cooke F, Lui K, Oei J. Effects of breast milk on the severity and outcome of neonatal abstinence syndrome among infants of drug-dependent mothers. Pediatrics 2006; 117 (06) e1163-e1169
  • 67 Kocherlakota P. Neonatal abstinence syndrome. Pediatrics 2014; 134 (02) e547-e561
  • 68 Osborn DA, Jeffery HE, Cole MJ. Opiate treatment for opiate withdrawal in newborn infants. Cochrane Database Syst Rev 2010; (10) CD002059
  • 69 Osborn DA, Jeffery HE, Cole MJ. Sedatives for opiate withdrawal in newborn infants. Cochrane Database Syst Rev 2010; (10) CD002053
  • 70 Patrick SW, Kaplan HC, Passarella M, Davis MM, Lorch SA. Variation in treatment of neonatal abstinence syndrome in US children's hospitals, 2004-2011. J Perinatol 2014; 34 (11) 867-872
  • 71 Asti L, Magers JS, Keels E, Wispe J, McClead Jr RE. A quality improvement project to reduce length of stay for neonatal abstinence syndrome. Pediatrics 2015; 135 (06) e1494-e1500
  • 72 Marcellus L. Care of substance-exposed infants: the current state of practice in Canadian hospitals. J Perinat Neonatal Nurs 2002; 16 (03) 51-68
  • 73 Benitz WE. ; Committee on Fetus and Newborn, American Academy of Pediatrics. Hospital stay for healthy term newborn infants. Pediatrics 2015; 135 (05) 948-953
  • 74 Comprehensive Addiction and Recovery Act (CARA) of 2016. Public Law Number 106–310. Stature Number 110
  • 75 Lester BM, Lagasse LL. Children of addicted women. J Addict Dis 2010; 29 (02) 259-276
  • 76 Ornoy A, Daka L, Goldzweig G. , et al. Neurodevelopmental and psychological assessment of adolescents born to drug-addicted parents: effects of SES and adoption. Child Abuse Negl 2010; 34 (05) 354-368
  • 77 Ornoy A. The impact of intrauterine exposure versus postnatal environment in neurodevelopmental toxicity: long-term neurobehavioral studies in children at risk for developmental disorders. Toxicol Lett 2003; 140-141: 171-181
  • 78 Walhovd KB, Moe V, Slinning K. , et al. Volumetric cerebral characteristics of children exposed to opiates and other substances in utero. Neuroimage 2007; 36 (04) 1331-1344
  • 79 Ko JY, Patrick SW, Tong VT, Patel R, Lind JN, Barfield WD. Incidence of neonatal abstinence syndrome - 28 States, 1999-2013. Morb Mortal Wkly Rep 2016; 65 (31) 799-802