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Synthesis 2018; 50(09): 1841-1848
DOI: 10.1055/s-0037-1609224
DOI: 10.1055/s-0037-1609224
paper
Noscapine Derivatives as New Chiral Catalysts in Asymmetric Synthesis: Highly Enantioselective Addition of Diethylzinc to Aldehydes
The authors would like to thank the Iran National Science Foundation (INSF, grant number 94-S-43569) for financial support of the work.Further Information
Publication History
Received: 01 January 2018
Accepted after revision: 09 January 2018
Publication Date:
05 February 2018 (online)
Abstract
Noscapine, a natural alkaloid, has never been used as a parent scaffold in chiral induction. The first examples of noscapinoid compounds as efficient catalysts in asymmetric synthesis are now reported. Three derivatives of noscapine were synthesized from its reaction with different Grignard reagents. Asymmetric addition of diethylzinc to aldehydes was performed in the presence of these catalysts in high yields and good to excellent ees.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609224.
- Supporting Information
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