Regioselective Synthesis of Dihydro-1H-furo[b]indol-1-ones and Their Carbanionic Reactivity

Abstract

A general synthesis of 3,4-dihydro-1H-furo[b]indol-1-ones, representing a furanone-fused pyrrole unit, has been developed. The dehydrohalogenative cyclization of 4-aminofuranones was achieved by reaction with Pd(OAc)₂ and DABCO in DMF. The corresponding N-protected indolones undergo alkylation at C3.

Key words

γ-lactone-fused heterocycles - furoindolones - regioselectivity - carbanions

• References

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