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Am J Perinatol 2018; 35(11): 1113-1118
DOI: 10.1055/s-0038-1641590
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Relationship between In Vitro Fertilization and Neonatal Outcomes in Very Low Birth Weight Preterm Infants

Khalid Al-Hathlol
1   Department of Neonatal Intensive Care, King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, College of Medicine, Riyadh, Kingdom of Saudi Arabia
› Author Affiliations
Further Information

Publication History

02 October 2017

26 February 2018

Publication Date:
10 April 2018 (online)

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Abstract

Objective To assess the association of in vitro fertilization (IVF) with neonatal outcomes and duration of stay in neonatal intensive care unit (NICU) among very low birth weight (VLBW) preterm infants.

Methods This was a cohort study of VLBW preterm infants admitted to NICU over 15 years. We assessed neonatal outcomes including composite outcome of mortality or severe morbidity, risk for major birth defects, survival without severe morbidity, and the duration of NICU stay across three birth-year epochs.

Results A total of 1,533 infants were eligible for data analysis. Of these, 236 were born following IVF and 1,297 were born following spontaneous conception (SC). After adjustment for baseline variables, regression analysis revealed no statistically significant differences between IVF and SC groups in terms of the composite outcome of mortality or severe morbidity, risk for major birth defects, survival without severe morbidity, or duration of NICU stay.

Conclusion Among VLBW preterm infants, IVF had no detectable relationship with neonatal outcomes and duration of NICU stay. These findings can help provide guidance in professional counseling of affected families.

Keywords

VLBW - infants - outcomes - IVF
 

  • References

  • 1 Wang J, Sauer MV. In vitro fertilization (IVF): a review of 3 decades of clinical innovation and technological advancement. Ther Clin Risk Manag 2006; 2 (04) 355-364
    CrossrefPubMedGoogle Scholar
  • 2 Fortunato A, Tosti E. The impact of in vitro fertilization on health of the children: an update. Eur J Obstet Gynecol Reprod Biol 2011; 154 (02) 125-129
    CrossrefPubMedGoogle Scholar
  • 3 Davies MJ, Moore VM, Willson KJ. , et al. Reproductive technologies and the risk of birth defects. N Engl J Med 2012; 366 (19) 1803-1813
    CrossrefPubMedGoogle Scholar
  • 4 Misund AR, Nerdrum P, Diseth TH. Mental health in women experiencing preterm birth. BMC Pregnancy Childbirth 2014; 14: 263
    CrossrefPubMedGoogle Scholar
  • 5 Barnes M, Roiko A, Reed R, Williams C, Willcocks K. Outcomes for women and infants following assisted conception: implications for perinatal education, care, and support. J Perinat Educ 2012; 21 (01) 18-23
    CrossrefPubMedGoogle Scholar
  • 6 Messerschmidt A, Olischar M, Birnbacher R, Weber M, Pollak A, Leitich H. Perinatal outcome of preterm infants <1500 g after IVF pregnancies compared with natural conception. Arch Dis Child Fetal Neonatal Ed 2010; 95 (03) F225-F229
    CrossrefPubMedGoogle Scholar
  • 7 Picaud JC, Chalies S, Combes C, Mercier G, Dechaud H, Cambonie G. Neonatal mortality and morbidity in preterm infants born from assisted reproductive technologies. Acta Paediatr 2012; 101 (08) 846-851
    CrossrefPubMedGoogle Scholar
  • 8 Stevenson DK, Wright LL, Lemons JA. , et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1993 through December 1994. Am J Obstet Gynecol 1998; 179 (6 Pt 1): 1632-1639
    CrossrefPubMedGoogle Scholar
  • 9 Lubchenco LO, Hansman C, Boyd E. Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks. Pediatrics 1966; 37 (03) 403-408
    CrossrefPubMedGoogle Scholar
  • 10 Pinborg A, Loft A, Rasmussen S. , et al. Neonatal outcome in a Danish national cohort of 3438 IVF/ICSI and 10,362 non-IVF/ICSI twins born between 1995 and 2000. Hum Reprod 2004; 19 (02) 435-441
    CrossrefPubMedGoogle Scholar
  • 11 Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 2002; 346 (10) 725-730
    CrossrefPubMedGoogle Scholar
  • 12 Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92 (04) 529-534
    CrossrefPubMedGoogle Scholar
  • 13 Allan WC, Philip AG. Neonatal cerebral pathology diagnosed by ultrasound. Clin Perinatol 1985; 12 (01) 195-218
    CrossrefPubMedGoogle Scholar
  • 14 American Academy of Pediatrics. An international classification of retinopathy of prematurity. Pediatrics 1984; 74 (01) 127-133
    PubMedGoogle Scholar
  • 15 Bancalari E, Claure N. Definitions and diagnostic criteria for bronchopulmonary dysplasia. Semin Perinatol 2006; 30 (04) 164-170
    CrossrefPubMedGoogle Scholar
  • 16 Bell MJ, Ternberg JL, Feigin RD. , et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 1978; 187 (01) 1-7
    CrossrefPubMedGoogle Scholar
  • 17 Isayama T, Lee SK, Mori R. , et al; Canadian Neonatal Network; Neonatal Research Network of Japan. Comparison of mortality and morbidity of very low birth weight infants between Canada and Japan. Pediatrics 2012; 130 (04) e957-e965
    Google Scholar
  • 18 Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD. ; National Institute of Child Health and Human Development Neonatal Research Network. Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999. Pediatrics 2005; 115 (06) 1645-1651
    CrossrefPubMedGoogle Scholar
  • 19 Linder N, Haskin O, Levit O. , et al. Risk factors for intraventricular hemorrhage in very low birth weight premature infants: a retrospective case-control study. Pediatrics 2003; 111 (5 Pt 1): e590-e595
    CrossrefPubMedGoogle Scholar
  • 20 Chan RV, Yonekawa Y, Morrison MA. , et al. Association between assisted reproductive technology and advanced retinopathy of prematurity. Clin Ophthalmol 2010; 4: 1385-1390
    PubMedGoogle Scholar
  • 21 Shah V, Alwassia H, Shah K, Yoon W, Shah P. Neonatal outcomes among multiple births ≤ 32 weeks gestational age: does mode of conception have an impact? A cohort study. BMC Pediatr 2011; 11: 54
    CrossrefPubMedGoogle Scholar
  • 22 Stewart JE, Allred EN, Collins M. , et al. Risk of cranial ultrasound abnormalities in very-low-birth-weight infants conceived with assisted reproductive techniques. J Perinatol 2002; 22 (01) 37-45
    CrossrefPubMedGoogle Scholar
  • 23 Schimmel MS, Hammerman C, Lusky A, Reichman B. Very low-birth-weight-infants conceived by in vitro fertilization are not at higher risk for mortality and morbidity: a population-based study. Fertil Steril 2006; 85 (04) 907-912
    CrossrefPubMedGoogle Scholar
  • 24 Chiarelli L, Mirea L, Yang J, Lee SK, Shah PS. ; on behalf of the Canadian Neonatal Network. Neonatal outcomes in very preterm singleton infants conceived using assisted reproductive technologies. Am J Perinatol 2015; 32 (06) 515-522
    Article in Thieme ConnectPubMedGoogle Scholar
  • 25 Hansen M, Bower C, Milne E, de Klerk N, Kurinczuk JJ. Assisted reproductive technologies and the risk of birth defects--a systematic review. Hum Reprod 2005; 20 (02) 328-338
    CrossrefPubMedGoogle Scholar
  • 26 Koo KY, Kim JE, Lee SM. , et al. Effect of severe neonatal morbidities on long term outcome in extremely low birthweight infants. Korean J Pediatr 2010; 53 (06) 694-700
    CrossrefPubMedGoogle Scholar
  • 27 Corchia C, Da Frè M, Di Lallo D. , et al. Mortality and major morbidities in very preterm infants born from assisted conception or naturally conceived: results of the area-based ACTION study. BMC Pregnancy Childbirth 2014; 14: 307
    CrossrefPubMedGoogle Scholar