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Am J Perinatol 2019; 36(10): 1090-1096
DOI: 10.1055/s-0038-1676490
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Impact of Time to Neonatal Transport on Outcomes of Transient Tachypnea of the Newborn

Katsuya Hirata
1   Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
,
Masatoshi Nozaki
1   Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
,
Narutaka Mochizuki
1   Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
,
Shinya Hirano
1   Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
,
Kazuko Wada
1   Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
› Author Affiliations
Funding None.
Further Information

Publication History

28 August 2018

28 October 2018

Publication Date:
14 December 2018 (online)

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Abstract

Objective To assess effects of neonatal transport on transient tachypnea of the newborn (TTN) in outborn term neonates.

Study Design This retrospective cohort study included 66 term neonates diagnosed with TTN and transported to the Osaka Women's and Children's Hospital neonatal intensive care unit between January 2003 and March 2018. A multivariate logistic regression analysis identified perinatal and neonatal transport factors associated with adverse short-term outcomes defined as mechanical ventilation >48 hours, continuous positive airway pressure >72 hours, pulmonary hemorrhage, and requirement for inhaled nitric oxide, thoracentesis, or surfactant replacement therapy.

Results A lower gestational age (GA) (37.7 [37.2, 38.3] vs. 39.6 [37.8, 40.3] weeks, p = 0.002), longer time to neonatal transport (10.0 [4.3, 25.5] vs. 5.5 [2.7, 9.7] hours, p = 0.01), and higher respiratory rates during transport (70 [60, 85] vs. 60 [55, 78.8] breaths/min, p = 0.04) were significantly associated with adverse short-term outcomes. After adjusting for GA, sex, cesarean section, and time to neonatal transport, GA (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.24–0.87) and time to neonatal transport (OR, 1.07; 95% CI, 1.01–1.13) were significantly associated with adverse outcomes.

Conclusion Short-term adverse prognosis of TTN is strongly associated with a lower GA and longer time between birth and neonatal transport.

Keywords

neonatal - neonatal transport - outborn term neonate - transient tachypnea of the newborns

Authors' Contributions

K.H. conceptualized and designed the study, contributed to the data analysis, and drafted the article. M.N., N.M., S.H., and K.W. reviewed the study results and gave conceptual suggestions. All authors reviewed the draft article and approved the final article for publication.