Journal of Pediatric Epilepsy 2018; 07(03): 097-102
DOI: 10.1055/s-0038-1676537
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Anxiety in Children and Adolescents with Epilepsy

David W. Dunn
1   Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, United States
,
Kelda Walsh
1   Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, United States
› Author Affiliations
Further Information

Publication History

29 May 2018

20 September 2018

Publication Date:
14 December 2018 (online)

Abstract

Anxiety is a common comorbidity in children with epilepsy, though often overlooked and undertreated. Fear and worry are common reactions of children with epilepsy and their parents. Risk factors are multiple and include demographical, epilepsy-related, genetic, and family variables. Anxiety negatively affects health-related quality of life (QOL) and may contribute to poor seizure control. Appropriate treatment of anxiety in children with epilepsy should follow practice guidelines developed for treatment of anxiety in children without epilepsy and consist of education, counseling, and potentially psychopharmacology.

 
  • References

  • 1 McDermott S, Mani S, Krishnaswami S. A population-based analysis of specific behavior problems associated with childhood seizures. J Epilepsy 1995; 8 (02) 110-118
  • 2 Berg AT, Vickrey BG, Testa FM, Levy SR, Shinnar S, DiMario F. Behavior and social competency in idiopathic and cryptogenic childhood epilepsy. Dev Med Child Neurol 2007; 49 (07) 487-492
  • 3 Russ SA, Larson K, Halfon N. A national profile of childhood epilepsy and seizure disorder. Pediatrics 2012; 129 (02) 256-264
  • 4 Reilly C, Atkinson P, Das KB. , et al. Neurobehavioral comorbidities in children with active epilepsy: a population-based study. Pediatrics 2014; 133 (06) e1586-e1593
  • 5 Reilly C, Atkinson P, Chin RF. , et al. Symptoms of anxiety and depression in school-aged children with active epilepsy: a population-based study. Epilepsy Behav 2015; 52 (Pt A): 174-179
  • 6 Wagner JL, Wilson DA, Smith G, Malek A, Selassie AW. Neurodevelopmental and mental health comorbidities in children and adolescents with epilepsy and migraine: a response to identified research gaps. Dev Med Child Neurol 2015; 57 (01) 45-52
  • 7 Oh A, Thurman DJ, Kim H. Comorbidities and risk factors associated with newly diagnosed epilepsy in the U.S. pediatric population. Epilepsy Behav 2017; 75: 230-236
  • 8 Tellez-Zenteno JF, Patten SB, Jetté N, Williams J, Wiebe S. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia 2007; 48 (12) 2336-2344
  • 9 Ettinger AB, Weisbrot DM, Nolan EE. , et al. Symptoms of depression and anxiety in pediatric epilepsy patients. Epilepsia 1998; 39 (06) 595-599
  • 10 Alwash RH, Hussein MJ, Matloub FF. Symptoms of anxiety and depression among adolescents with seizures in Irbid, Northern Jordan. Seizure 2000; 9 (06) 412-416
  • 11 Adewuya AO, Ola BA. Prevalence of and risk factors for anxiety and depressive disorders in Nigerian adolescents with epilepsy. Epilepsy Behav 2005; 6 (03) 342-347
  • 12 Caplan R, Siddarth P, Gurbani S, Hanson R, Sankar R, Shields WD. Depression and anxiety disorders in pediatric epilepsy. Epilepsia 2005; 46 (05) 720-730
  • 13 Caplan R, Siddarth P, Stahl L. , et al. Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities. Epilepsia 2008; 49 (11) 1838-1846
  • 14 Jones JE, Watson R, Sheth R. , et al. Psychiatric comorbidity in children with new onset epilepsy. Dev Med Child Neurol 2007; 49 (07) 493-497
  • 15 Dunn DW, Austin JK, Perkins SM. Prevalence of psychopathology in childhood epilepsy: categorical and dimensional measures. Dev Med Child Neurol 2009; 51 (05) 364-372
  • 16 Scott AJ, Sharpe L, Hunt C, Gandy M. Anxiety and depressive disorders in people with epilepsy: a meta-analysis. Epilepsia 2017; 58 (06) 973-982
  • 17 Rai D, Kerr MP, McManus S, Jordanova V, Lewis G, Brugha TS. Epilepsy and psychiatric comorbidity: a nationally representative population-based study. Epilepsia 2012; 53 (06) 1095-1103
  • 18 Jones JE, Jackson DC, Chambers KL. , et al. Children with epilepsy and anxiety: Subcortical and cortical differences. Epilepsia 2015; 56 (02) 283-290
  • 19 Cianchetti C, Bianchi E, Guerrini R. , et al; TASCA Study Group. Symptoms of anxiety and depression and family's quality of life in children and adolescents with epilepsy. Epilepsy Behav 2018; 79: 146-153
  • 20 Baker GA, Spector S, McGrath Y, Soteriou H. Impact of epilepsy in adolescence: a UK controlled study. Epilepsy Behav 2005; 6 (04) 556-562
  • 21 Rosenberg HJ, Rosenberg SD, Williamson PD, Wolford II GL. A comparative study of trauma and posttraumatic stress disorder prevalence in epilepsy patients and psychogenic nonepileptic seizure patients. Epilepsia 2000; 41 (04) 447-452
  • 22 Baumer JH, David TJ, Valentine SJ, Roberts JE, Hughes BR. Many parents think their child is dying when having a first febrile convulsion. Dev Med Child Neurol 1981; 23 (04) 462-464
  • 23 Besag FMC, Nomayo A, Pool F. The reactions of parents who think that a child is dying in a seizure--in their own words. Epilepsy Behav 2005; 7 (03) 517-523
  • 24 Iseri PK, Ozten E, Aker AT. Posttraumatic stress disorder and major depressive disorder is common in parents of children with epilepsy. Epilepsy Behav 2006; 8 (01) 250-255
  • 25 Carmassi C, Corsi M, Gesi C. , et al. DSM-5 criteria for PTSD in parents of pediatric patients with epilepsy: What are the changes with respect to DSM-IV-TR?. Epilepsy Behav 2017; 70 (Pt A): 97-103
  • 26 Vega C, Guo J, Killory B. , et al. Symptoms of anxiety and depression in childhood absence epilepsy. Epilepsia 2011; 52 (08) e70-e74
  • 27 McNelis A, Musick B, Austin J, Dunn D, Creasy K. Psychosocial care needs of children with new-onset seizures. 2. J Neurosci Nurs 1998; 30 (03) 161-165
  • 28 Stevanovic D, Jancic J, Topalovic M, Tadic I. Agreement between children and parents when reporting anxiety and depressive symptoms in pediatric epilepsy. Epilepsy Behav 2012; 25 (02) 141-144
  • 29 Save-Pédebos J, Bellavoine V, Goujon E. , et al. Difference in anxiety symptoms between children and their parents facing a first seizure or epilepsy. Epilepsy Behav 2014; 31: 97-101
  • 30 Ramaglia G, Romeo A, Viri M, Lodi M, Sacchi S, Cioffi G. Impact of idiopathic epilepsy on mothers and fathers: strain, burden of care, worries and perception of vulnerability. Epilepsia 2007; 48 (09) 1810-1814
  • 31 Spitzer RL, Kroenke K, Williams JBW, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 2006; 166 (10) 1092-1097
  • 32 Jones JE. Treating anxiety disorders in children and adolescents with epilepsy: what do we know?. Epilepsy Behav 2014; 39: 137-142
  • 33 Birmaher B, Brent DA, Chiappetta L, Bridge J, Monga S, Baugher M. Psychometric properties of the screen for child anxiety related emotional disorders (SCARED): a replication study. J Am Acad Child Adolesc Psychiatry 1999; 38 (10) 1230-1236
  • 34 Nauta MH, Scholing A, Rapee RM, Abbott M, Spence SH, Waters A. A parent-report measure of children's anxiety: psychometric properties and comparison with child-report in a clinic and normal sample. Behav Res Ther 2004; 42 (07) 813-839
  • 35 Achenbach TM, Rescorla LA. Manual for the ASEBA School-Age: Forms and Profiles. Burlington, VT, University of Vermont, Research Center for Children, Youth, and Families; 2001
  • 36 Bourdon KH, Goodman R, Rae DS, Simpson G, Koretz DS. The Strengths and Difficulties Questionnaire: U.S. normative data and psychometric properties. J Am Acad Child Adolesc Psychiatry 2005; 44 (06) 557-564
  • 37 Chiesa V, Gardella E, Tassi L. , et al. Age-related gender differences in reporting ictal fear: analysis of case histories and review of the literature. Epilepsia 2007; 48 (12) 2361-2364
  • 38 Kanner AM, Soto A, Gross-Kanner H. Prevalence and clinical characteristics of postictal psychiatric symptoms in partial epilepsy. Neurology 2004; 62 (05) 708-713
  • 39 Ekinci O, Titus JB, Rodopman AA, Berkem M, Trevathan E. Depression and anxiety in children and adolescents with epilepsy: prevalence, risk factors, and treatment. Epilepsy Behav 2009; 14 (01) 8-18
  • 40 Reilly C, Agnew R, Neville BGR. Depression and anxiety in childhood epilepsy: a review. Seizure 2011; 20 (08) 589-597
  • 41 Berg AT, Caplan R, Hesdorffer DC. Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy. Epilepsy Behav 2011; 20 (03) 550-555
  • 42 de Oliveira GN, Kummer A, Salgado JV. , et al. Psychiatric disorders in temporal lobe epilepsy: an overview from a tertiary service in Brazil. Seizure 2010; 19 (08) 479-484
  • 43 Kaplan PW. Obsessive-compulsive disorder in chronic epilepsy. Epilepsy Behav 2011; 22 (03) 428-432
  • 44 Afzal KI, Anam S, Hunter SJ. The effects of antiepileptic drugs on pediatric cognition, mood, and behavior. J Pediatr Epilepsy 2017; 6: 3-18
  • 45 Mula M, Pini S, Cassano GB. The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence. J Clin Psychopharmacol 2007; 27 (03) 263-272
  • 46 Hesdorffer DC, Caplan R, Berg AT. Familial clustering of epilepsy and behavioral disorders: evidence for a shared genetic basis. Epilepsia 2012; 53 (02) 301-307
  • 47 Schraegle WA, Titus JB. The influence of endophenotypic, disease-specific, and environmental variables on the expression of anxiety in pediatric epilepsy. Epilepsy Behav 2017; 75: 90-96
  • 48 Adelöw C, Andersson T, Ahlbom A, Tomson T. Hospitalization for psychiatric disorders before and after onset of unprovoked seizures/epilepsy. Neurology 2012; 78 (06) 396-401
  • 49 Jones C, Reilly C. Parental anxiety in childhood epilepsy: A systematic review. Epilepsia 2016; 57 (04) 529-537
  • 50 Reilly C, Atkinson P, Memon A. , et al. Symptoms of depression, anxiety, and stress in parents of young children with epilepsy: a case controlled population-based study. Epilepsy Behav 2018; 80: 177-183
  • 51 Puka K, Widjaja E, Smith ML. The influence of patient, caregiver, and family factors on symptoms of anxiety and depression in children and adolescents with intractable epilepsy. Epilepsy Behav 2017; 67: 45-50
  • 52 McKee HR, Privitera MD. Stress as a seizure precipitant: identification, associated factors, and treatment options. Seizure 2017; 44: 21-26
  • 53 Kanner AM, Barry JJ, Gilliam F, Hermann B, Meador KJ. Depressive and anxiety disorders in epilepsy: do they differ in their potential to worsen common antiepileptic drug-related adverse events?. Epilepsia 2012; 53 (06) 1104-1108
  • 54 Stevanovic D, Jancic J, Lakic A. The impact of depression and anxiety disorder symptoms on the health-related quality of life of children and adolescents with epilepsy. Epilepsia 2011; 52 (08) e75-e78
  • 55 Garcia-Ramos C, Lin JJ, Bonilha L. , et al. Disruptions in cortico-subcortical covariance networks associated with anxiety in new-onset childhood epilepsy. Neuroimage Clin 2016; 12: 815-824
  • 56 Hamiwka LD, Yu CG, Hamiwka LA, Sherman EM, Anderson B, Wirrell E. Are children with epilepsy at greater risk for bullying than their peers?. Epilepsy Behav 2009; 15 (04) 500-505
  • 57 Lewis MA, Salas I, de la Sota A, Chiofalo N, Leake B. Randomized trial of a program to enhance the competencies of children with epilepsy. Epilepsia 1990; 31 (01) 101-109
  • 58 Lewis MA, Hatton CL, Salas I, Leake B, Chiofalo N. Impact of the children's epilepsy program on parents. Epilepsia 1991; 32 (03) 365-374
  • 59 Tieffenberg JA, Wood EI, Alonso A, Tossutti MS, Vicente MF. A randomized field trial of ACINDES: a child-centered training model for children with chronic illnesses (asthma and epilepsy). J Urban Health 2000; 77 (02) 280-297
  • 60 Snead K, Ackerson J, Bailey K, Schmitt MM, Madan-Swain A, Martin RC. Taking charge of epilepsy: the development of a structured psychoeducational group intervention for adolescents with epilepsy and their parents. Epilepsy Behav 2004; 5 (04) 547-556
  • 61 Buelow JM, Johnson CS, Perkins SM, Austin JK, Dunn DW. Creating Avenues for Parent Partnership (CAPP): an intervention for parents of children with epilepsy and learning problems. Epilepsy Behav 2013; 27 (01) 64-69
  • 62 Connolly SD, Bernstein GA. ; Work Group on Quality Issues. Practice parameter for the assessment and treatment of children and adolescents with anxiety disorders. J Am Acad Child Adolesc Psychiatry 2007; 46 (02) 267-283
  • 63 Wang Z, Whiteside SPH, Sim L. , et al. Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders; a systematic review and meta-analysis. JAMA Pediatr 2017; 171 (11) 1049-1056
  • 64 Blocher JB, Fujikawa M, Sung C, Jackson DC, Jones JE. Computer-assisted cognitive behavioral therapy for children with epilepsy and anxiety: a pilot study. Epilepsy Behav 2013; 27 (01) 70-76
  • 65 Martinović Z, Simonović P, Djokić R. Preventing depression in adolescents with epilepsy. Epilepsy Behav 2006; 9 (04) 619-624
  • 66 Gandy M, Sharpe L, Perry KN. Cognitive behavior therapy for depression in people with epilepsy: a systematic review. Epilepsia 2013; 54 (10) 1725-1734
  • 67 Strawn JR, Welge JA, Wehry AM, Keeshin B, Rynn MA. Efficacy and tolerability of antidepressants in pediatric anxiety disorders: a systematic review and meta-analysis. Depress Anxiety 2015; 32 (03) 149-157
  • 68 Thomé-Souza MS, Kuczynski E, Valente KD. Sertraline and fluoxetine: safe treatments for children and adolescents with epilepsy and depression. Epilepsy Behav 2007; 10 (03) 417-425
  • 69 Alper K, Schwartz KA, Kolts RL, Khan A. Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports. Biol Psychiatry 2007; 62 (04) 345-354
  • 70 Kanner AM. Most antidepressant drugs are safe for patients with epilepsy at therapeutic doses: A review of the evidence. Epilepsy Behav 2016; 61: 282-286