Abstract
Objective This study aimed to determine whether early diabetes testing is associated with differences
in perinatal outcomes among pregnant women with obesity (body mass index ≥30 kg/m2).
Study Design We conducted a retrospective cohort study of singleton pregnancies from 2012 to 2014
at a large academic medical center which examined the association of diabetes testing
(HBA1c, 50 g glucose challenge test, or 100 g oral glucose tolerance test) before
24 weeks with perinatal outcomes using propensity score modeling and logistic regression.
Results Among women with obesity, 790 out of 2,698 (29.3%) underwent early diabetes testing.
Propensity score modeling demonstrated that early testing was associated with higher
rates of diabetes diagnosis (odds ratio [OR]: 1.62, 95% confidence interval [CI]:
1.10–2.37, p = 0.01) and a trend toward small for gestational age birth weight (OR: 1.38, 95%
CI: 1.00–1.90, p = 0.05) and neonatal composite morbidity (OR: 1.25, 95% CI: 1.00–1.57, p = 0.05) compared with routine testing. Women with inadequate weight gain were more
likely a small for gestational age (SGA) infant if they underwent early testing compared
with those with routine testing alone (19.8 vs. 11.6%, p = 0.01).
Conclusion Early testing targets higher risk women and yields a higher diabetes diagnosis rate,
but inadequate weight gain in these women may increase risk SGA birth weight and neonatal
morbidity. Randomized clinical trials are urgently needed to assess whether early
diabetes testing improves outcomes in women with obesity.
Keywords
gestational diabetes mellitus - diabetes screening - obesity - neonatal morbidity
