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Pre-Exposure Prophylaxis (PrEP)
Method for the Synthesis, Compositions and Use of 2′-Deoxy-5-fluoro-3′-thiacytidine and Related Compounds.
US Patent 5210085, 1993
US Patent 5733788, 1998
18 October 2019 (online)
Pre-exposure prophylaxis (PrEP) is a HIV prevention method for uninfected individuals. It virtually eliminates the risk of getting HIV if taken consistently and correctly. Truvada is the drug used for PrEP. It contains a combination of emtricitabine and tenofovir disoproxil fumarate (prodrug).
Emtricitabine was synthesized by nucleosidation of a readily available oxathiolane derivate with the silylated nucleobase B. The high level of stereoselectivity is provided by in situ complexation of the oxathiolane and the Lewis acid. Tenofovir was synthesized in just six steps starting from commercially available (S)-glycidol.