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Synfacts 2019; 15(10): 1135
DOI: 10.1055/s-0039-1690919
DOI: 10.1055/s-0039-1690919
Metals in Synthesis
Gold-Catalyzed Enantioselective Cyclizations of Enynes through Remote Enantioinduction
Zuccarello G,
Mayans JG,
Escofet I,
Scharnagel D,
Kirillova MS,
Pérez-Jimeno AH,
Calleja P,
Boothe JR,
Echavarren AM.
* Barcelona Institute of Science and Technology and Universitat Rovira i Virgili, Tarragona, Spain
Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote C 2-Chiral Element.
J. Am. Chem. Soc. 2019;
141: 11858-11863
Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote C 2-Chiral Element.
J. Am. Chem. Soc. 2019;
141: 11858-11863
Further Information
Publication History
Publication Date:
17 September 2019 (online)
Significance
Various cyclizations were realized in an enantioselective fashion through the use of a modified JohnPhos ligand with a distal C 2 2,5-diarrylpyrrolidine.
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Comment
Hydrocyclization products were used successfully in the first enantioselective total syntheses of three natural products from the carexane family.
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