Sang R,
Kucmierczyk P,
Dühren R,
Razzaq R,
Dong K,
Liu J,
Franke R.
*
Jackstell R,
Beller M.
* Evonik Performance Materials gmbh, marl, Ruhr-Universität, Bochum, and Universität
Rostock, Germany
Synthesis of Carboxylic Acids by Palladium-Catalyzed Hydroxycarbonylation.
Angew. Chem. Int. Ed. 2019;
58: 14365-14373
Key words
carboxylic acids - palladium catalysis - hydroxy-carbonylation
Significance
The authors report a very general and high yielding palladium-catalyzed synthesis
of carboxylic acids, starting from alkenes. The method is performed in aqueous environment
and uses only 0.25 mol% of Pd(acac)2. High pressured carbon monoxide is used as ′CO′ source, ensuring a good atom economy.
Comment
Various substituted alkenes (over 40 examples) have been successfully transformed
into their corresponding carboxylic acids. The method provides the product in high
n/iso ratio and can tolerate highly reactive functional groups, such as ketones or phosphates.
