Studies towards the Total Synthesis of Kadcotrione B

Abstract

A convergent and efficient approach towards the total synthesis of Kadcotrione B is described. For this purpose, the syntheses of two fragments, 6/6/5-fused tricyclic ring and C-9 side chain, were accomplished. The salient features of these syntheses are the utilization of aldol condensation, Evans aldol reaction, Horner–Wadsworth–Emmons olefination, Michael addition, Robinson annulation, and Wacker oxidation.

Key words

aldol condensation - diastereoselectivity - Hagiwara–Weiland­–Miescher ketone - Horner–Wadsworth–Emmons reaction - Kadcotrione­ - Michael addition

• References

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