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Am J Perinatol 2021; 38(05): 507-514
DOI: 10.1055/s-0039-1698837
Original Article

Risk of Neonatal Short-Term Adverse Outcomes Associated with Noninfectious Intrapartum Hyperthermia: A Nested Case-Control Retrospective Study

Hao Zhu
1   Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
,
Jiangnan Wu
2   Epidemiology laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
,
Yijia Yang
1   Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
,
Xiaotian Li
1   Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
,
Rong Hu
1   Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
› Author Affiliations Funding This study was supported by the National Key R&D Program of China (2016YFC100403) and the National Natural Science Foundation of China (Grant No. 81571460).
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Abstract

Objective This study aimed to identify risk factors for adverse neonatal outcomes in neonates born to mothers with noninfectious intrapartum hyperthermia.

Study Design A retrospective study was conducted of 460 singleton deliveries diagnosed with noninfectious intrapartum hyperthermia. Logistic regression was used to estimate the association between ante- and intrapartum risk factors and neonatal outcomes.

Results The 460 singleton pregnant women were 19 to 43 years of age. They developed an intrapartum temperature of ≥37.5°C somewhere between 340/7 to 414/7 weeks' gestation; 437 (95%) were nulliparous. Meconium-stained amniotic fluid was associated with positive pressure ventilation or intubation ventilation (odds ratio [OR] = 5.940, 95% confidence interval [CI]: 2.038–17.318), birth depression (OR = 6.288, 95% CI: 2.273–17.399), and wet lung (OR = 2.747, 95% CI: 1.322–5.709). Induction of labor with artificial rupture of membranes (AROM; OR = 2.632, 95% CI: 1.325–5.228) was associated with neonatal infections. Maternal temperature ≥ 38°C was associated with neonate's artery blood gas pH < 7.3 (OR = 2.366, 95%CI: 1.067–5.246) and wet lung (OR = 2.909, 95% CI: 1.515–5.586). Maternal elevated C-reactive protein (CRP) was associated with neonatal infections (OR = 1.993, 95% CI: 1.260–3.154) and wet lung (OR = 2.600, 95% CI: 1.306–5.178).

Conclusion Meconium-stained amniotic fluid, induction of labor, maternal temperature ≥ 38°C, and elevated CRP during labor were risk factors for adverse neonatal outcomes.

Keywords

maternal hyperthermia - noninfectious - meconium-stained amniotic fluid - induction of labor - neonatal short-term outcomes


Publication History

Received: 28 January 2019

Accepted: 06 September 2019

Article published online:
18 November 2019

© 2019. Thieme. All rights reserved.

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