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Synlett 2021; 32(04): 329-336
DOI: 10.1055/s-0040-1707326
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Designing the Secondary Coordination Sphere in Small-Molecule Catalysis

Inbal L. Zak‡
,
Santosh C. Gadekar‡
,
Anat Milo  ∗
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva, Israel
› Author AffiliationsThis research was supported by the Israel Science Foundation (Grant No. 1193/17). I. L. Z. gratefully acknowledges the BGU Faculty of Natural Sciences for an MSc excellence fellowship. S.C.G. gratefully acknowledges the Kreitman School of Advanced Graduate Studies, Ben-Gurion University of the Negev for a postdoctoral fellowship.
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Erratum - Designing the Secondary Coordination Sphere in Small-Molecule CatalysisSynlett 2024; 35(07): 832-832
DOI: 10.1055/s-0043-1763761

Abstract

The application of secondary-sphere interactions in catalysis was inspired by the hierarchical arrangement of the microenvironment of metalloprotein active sites and has been adopted mainly in organometallic catalysis. The study of such interactions has enabled the deliberate orientation of reaction components, leading to control over reactivity and selectivity by design. Although not as common, such interaction can play a decisive role in organocatalysis. Herein, we present several examples of small-molecule organometallic- and organocatalysis, highlighting the advantages offered by carefully designing the secondary sphere.

1 Introduction

2 Secondary-Sphere Design in Organometallic Catalysis

3 Secondary-Sphere Modification in Organocatalysis

4 Using Statistical Analysis to Systematically Tune and Probe Secondary-Sphere Interactions

5 Conclusion

Key words

secondary coordination sphere - noncovalent interactions - hydrogen bonds - organometallics - organocatalysis


Publication History

Received: 24 August 2020

Accepted after revision: 15 September 2020

Article published online:
12 October 2020

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