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Am J Perinatol 2021; 38(14): 1533-1539
DOI: 10.1055/s-0040-1713887
Original Article

Placenta Accreta Spectrum: In Vitro Fertilization and Non-In Vitro Fertilization and Placenta Accreta Spectrum in a Massachusetts Cohort

Anna M. Modest
1   Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
2   Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts
,
Thomas L. Toth
1   Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
2   Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts
3   Boston IVF Inc, Waltham, Massachusetts
,
Katherine M. Johnson
1   Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
2   Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts
,
Scott A. Shainker 
1   Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
2   Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts
› Author Affiliations Funding A.M.M. was supported by NIH T32 HD052458, Boston University Reproductive, Perinatal and Pediatric Epidemiology Training Program. A.M.M. and S.A.S. were funded, in part, by a grant from the Charles Koch Foundation. The National Institutes of Health and Charles Koch Foundation had no involvement in the research or preparation of this manuscript.
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Abstract

Objective The incidence of placenta accreta spectrum (PAS) has been increasing in the United States. In addition, there has also been an increase in the utilization of in vitro fertilization (IVF). The IVF pregnancies confer an increased risk of adverse obstetric and neonatal outcomes, but there is limited data on whether IVF is associated with PAS. The aim of this study is to assess the association between IVF and the risk of PAS.

Study Design This was a retrospective cohort study of deliveries from January 1, 2013 to August 1, 2018 at a tertiary hospital in the Massachusetts. IVF pregnancies were compared with non-IVF pregnancies, and PAS diagnosis was confirmed by histopathology reports. Hospital administrative data and medical record review were used, and supplemented with data from birth certificates from the Massachusetts Department of Public Health.

Results We identified 28,344 pregnancies that met inclusion criteria, of which 1,418 (5.0%) were IVF pregnancies. The overall incidence of PAS was 0.4% (2.2% in the IVF group and 0.3% in the non-IVF group). Women who underwent IVF had 5.5 times the risk of PAS (95% confidence interval [CI]: 3.4–8.7) compared with women in the non-IVF group, adjusted for maternal age, nulliparity, and year of delivery ([Table 5]). Compared with women in the non-IVF group, the IVF group had fewer prior cesarean deliveries (22.6 vs. 64.2%) and a lower prevalence of placenta previa (19.4 vs. 44.4%).

Conclusion Women with an IVF pregnancy carry an increased risk of PAS compared with non-IVF. Among women who underwent IVF, there was a lower prevalence of prior cesarean deliveries and placenta previa. Future work is needed to identify the mechanism of association for this increased risk as well as a reliable tool for antenatal detection in this cohort of women.

Key Points

  • IVF pregnancies have higher risk of PAS than non-IVF pregnancies.

  • IVF pregnancies with PAS do not exhibit common risk factors.

  • IVF may be an independent risk factor for PAS.

Keywords

abnormally invasive placenta - abnormal placentation - invasive placentation - placenta accreta spectrum - infertility - in vitro fertilization

Supplementary Material



Publication History

Received: 06 April 2020

Accepted: 28 May 2020

Article published online:
05 July 2020

© 2020. Thieme. All rights reserved.

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