Diffuse Alveolar Damage Correlation with Clinical Diagnosis of Pediatric Acute Respiratory Distress Syndrome

Abstract

Diffuse alveolar damage (DAD) is one of the pathological hallmarks of acute respiratory distress syndrome (ARDS). We aimed to compare pathological findings of DAD with clinical ARDS criteria. We re-evaluated 20 patients whose clinical autopsy revealed DAD. Total 11/20 patients with DAD (55%) met the 1994 American–European Consensus Conference and 7/17 (41%) met the 2012 Berlin clinical criteria. DAD showed only moderate correlation with current clinical ARDS definition. Oxygenation index (OI), seems to be the most valuable tool in predicting pulmonary damage severity, though OI is not listed in either of the previous definitions. We support the recommended use of OI by 2015 consensus conference.

Keywords

diffuse alveolar damage - acute respiratory distress syndrome - pediatric intensive care unit

Note

Ethical committee of Hacettepe University approved the study.

Authors' Contributions

E.S. conceptualized study design, analyzed the data, and drafted the manuscript for intellectual content. S.K. interpreted the data and revised the manuscript for intellectual content. B.B. and G.K. conceptualized study design, interpreted the data, and revised the manuscript for intellectual content.

Publikationsverlauf

Eingereicht: 25. März 2020

Angenommen: 26. Mai 2020

Artikel online veröffentlicht:
20. Juli 2020

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