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Am J Perinatol 2022; 39(06): 609-615
DOI: 10.1055/s-0040-1718369
Original Article

Suspected or Proven Early-Onset Sepsis and NLR, PLR, and MPV Parameters in Neonates with Born through MSAF

Ahmet Taşkın
1   Department of Pediatrics, Bagcilar Training and Research Hospital, Istanbul, Turkey
,
Emrah Can 
2   Neonatal Intensive Care Unit, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, Istanbul, Turkey
,
Şahin Hamilçıkan
2   Neonatal Intensive Care Unit, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, Istanbul, Turkey
› Author Affiliations Funding None.
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Abstract

Objective It was aimed to determine the presence of early-onset sepsis in newborns born through meconium-stained amniotic fluid (MSAF) and to investigate the changes of blood parameters in these neonates.

Study Design This cross-sectional observational study was performed with neonates born MSAF were divided into two groups as C-reactive protein (CRP) and procalcitonin (PCT) positive and negative group.

Results A total of 3,096 neonates enrolled in this study, and of these 272 with MSAF (8.7%), 76 (27.9%) with neonates were Group I and 196 (72.1%) neonates were Group II. Group I had significantly higher CRP and PCT values and monocyte values significantly lower than Group II, but there were no statistically significant differences between other investigated blood count parameters. There was no association between the platelet, mean platelet volume (MPV), plateletcrit, platelet distribution width, neutrphil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) and sepsis in neonates born MSAF. The following areas under the receiver operating characteristic curve were found, respectively: MPV was 0.49 (0.36–0.55), NLR was 0.54 (0.48–0.60), PLR was 0.53 (0.47–0.59), and MLR was 0.54 (0.48–0.60).

Conclusion MSAF might be a risk factor for early-onset sepsis in neonates. However, MPV, NLR, PLR, and MLR values cannot be helpful for the detection of suspected or proven early-onset neonatal sepsis in born MSAF neonates.

Key Points

  • MSAF might be as a risk factor for EOS in neonates.

  • CRP and procalcitonin values may help to be determined at EOS in asymtomatic neonates with MSAF.

  • MPV, NLR, PLR, andMLR values do not seemto behelpful for the early detection of sepsis inmeconium-stained term neonates.

Keywords

MSAF - early-onset sepsis - neonate - complete blood count

Note

All procedures performed involving human participants follow the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards (ethical approval number: 2017–571).




Publication History

Received: 09 July 2020

Accepted: 25 August 2020

Article published online:
08 October 2020

© 2020. Thieme. All rights reserved.

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