A Case of Musicogenic Epilepsy

Abstract

Musicogenic epilepsy is a relatively rare form of epilepsy characterized by seizures triggered by specific music experiences, with an estimated prevalence of 1/10,000,000 population. In this article, we reported a case of 12-year-old boy patient with a history of recent onset focal seizures associated with an aura of formed visual hallucinations, feeling of familiarity (déjà vu), and impending fear lasting for seconds to a minute followed by eye blinking, oral automatisms, and unresponsiveness for almost 15 minutes. These episodes, most often, were provoked by music. Video electroencephalogram (EEG) done in our institute was suggestive of reflex musicogenic epilepsy arising from the left anterior temporal lobe. Magnetic resonance imaging of the brain 3T with epilepsy protocol confirmed video EEG findings, with an abnormal signal intensity in the left hippocampal and mesial temporal lobe. Treatment included lifestyle modification and antiepileptic drugs.

Keywords

musicogenic epilepsy - reflex epilepsy - electroencephalogram - seizure - music

Publikationsverlauf

Eingereicht: 14. Dezember 2020

Angenommen: 01. Februar 2021

Artikel online veröffentlicht:
10. März 2021

• References

• 1 Okudan ZV, Özkara Ç. Reflex epilepsy: triggers and management strategies. Neuropsychiatr Dis Treat 2018; 14: 327-337
• 2 Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989; 30 (04) 389-399
• 3 Kasteleijn-Nolst Trenité DG. Provoked and reflex seizures: surprising or common?. Epilepsia 2012; 53 (Suppl. 04) 105-113
• 4 Avanzini G. Musicogenic seizures. Ann N Y Acad Sci 2003; 999: 95-102
• 5 Stern J. Musicogenic epilepsy. Handb Clin Neurol 2015; 129: 469-477
• 6 Pelliccia V, Villani F, Gozzo F, Gnatkovsky V, Cardinale F, Tassi L. Musicogenic epilepsy: astereo-electroencephalography study. Cortex 2019; 120: 582-587
• 7 Ellis L. The potential mechanism of musicogenic epilepsy and future research avenues. Bioscience Horizons: Int J Student Research 2017; 10: hzx004
• 8 Wieser HG, Hungerbühler H, Siegel AM, Buck A. Musicogenic epilepsy: review of the literature and case report with ictal single photon emission computed tomography. Epilepsia 1997; 38 (02) 200-207
• 9 Critchley M. Musicogenic epilepsy. Brain 1937; 60 (01) 13-27 . Doi: 10.1093/brain/60.1.13
• 10 Berg AT, Berkovic SF, Brodie MJ. et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia 2010; 51 (04) 676-685
• 11 Pittau F, Tinuper P, Bisulli F. et al. Videopolygraphic and functional MRI study of musicogenic epilepsy. A case report and literature review. Epilepsy Behav 2008; 13 (04) 685-692
• 12 Genc BO, Genc E, Taştekin G, Iihan N. Musicogenic epilepsy with ictal single photon emission computed tomography (SPECT): could these cases contribute to our knowledge of music processing?. Eur J Neurol 2001; 8 (02) 191-194
• 13 Bodner M, Muftuler LT, Nalcioglu O, Shaw GL. FMRI study relevant to the Mozart effect: brain areas involved in spatial-temporal reasoning. Neurol Res 2001; 23 (07) 683-690
• 14 Marrosu F, Barberini L, Puligheddu M. et al. Combined EEG/fMRI recording in musicogenic epilepsy. Epilepsy Res 2009; 84 (01) 77-81
• 15 Blood AJ, Zatorre RJ. Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. Proc Natl Acad Sci U S A 2001; 98 (20) 11818-11823
• 16 Diekmann V, Hoppner AC. Cortical network dysfunction in musicogenic epilepsy reflecting the role of snowballing emotional processes in seizure generation: an fMRI-EEG study. Epileptic Disord 2014; 16 (01) 31-44
• 17 Tayah TF, Abou-Khalil B, Gilliam FG, Knowlton RC, Wushensky CA, Gallagher MJ. Musicogenic seizures can arise from multiple temporal lobe foci: intracranial EEG analyses of three patients. Epilepsia 2006; 47 (08) 1402-1406
• 18 Lin KL, Wang HS, Kao PF. A young infant with musicogenic epilepsy. Pediatr Neurol 2003; 28 (05) 379-381
• 19 Nagahama Y, Kovach CK, Ciliberto M. et al. Localization of musicogenic epilepsy to Heschl's gyrus and superior temporal plane: case report. J Neurosurg 2018; 129 (01) 157-164
• 20 Wang ZI, Jin K, Kakisaka Y. et al. Interconnections in superior temporal cortex revealed by musicogenic seizure propagation. J Neurol 2012; 259 (10) 2251-2254
• 21 Zatorre RJ, Salimpoor VN. From perception to pleasure: music and its neural substrates. Proc Natl Acad Sci USA 2013; 110 (Suppl. 02) 10430-10437
• 22 Nuara A, Mirandola L, Fabbri-Destro M. et al. Spatio-temporal dynamics of interictal activity in musicogenic epilepsy: two case reports and a systematic review of the literature. Clin Neurophysiol 2020; 131 (10) 2393-2401
• 23 Pejović AT, Vojvodić N, Djukić T. et al. New-onset musicogenic epilepsy after temporal lobe epilepsy surgery. Epileptic Disord 2020; 22 (02) 202-206