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Am J Perinatol 2022; 39(01): 001-007
DOI: 10.1055/s-0041-1735624
SMFM Fellowship Series Article

Quick Sequential Organ Failure Assessment: Modifications for Identifying Maternal Morbidity and Mortality in Obstetrical Patients

Authors

  • Sarah G. Cagino

    1   Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Albany Medical Center, Albany, New York

  • Alexandra A. Burke

    2   Department of Obstetrics and Gynecology, Albany Medical Center, Albany, New York

  • Dorothea R. Letner

    2   Department of Obstetrics and Gynecology, Albany Medical Center, Albany, New York

  • Julie M. Leizer

    1   Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Albany Medical Center, Albany, New York

  • Craig M. Zelig

    1   Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Albany Medical Center, Albany, New York

Funding None.
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Abstract

Objective Screening tools, including the Systemic Inflammatory Response Syndrome (SIRS) criteria and Sequential Organ Failure Assessment (SOFA) criteria, have not been validated in the pregnant population. We aimed to determine if pregnancy-specific modifications to the quick SOFA (qSOFA) can improve prediction of severe maternal morbidity in pregnant women with serious infections.

Study Design We performed a retrospective cohort study of pregnant patients with severe infections admitted to a single institution from January 1, 2011, through December 31, 2017. The primary outcome was severe maternal morbidity, defined as a composite of adverse maternal outcomes: intensive care unit (ICU) admission for >48 hours, need for invasive monitoring (central line or arterial line), intubation, pharmacologic hemodynamic support (intravenous vasopressors or inotropes), and/or maternal death. A logistic regression was then applied and the resulting predictors were analyzed individually and in combination with receiver operating characteristic (ROC) curves to modify qSOFA for pregnancy, that is, qSOFA-P.

Results Analysis of 104 pregnant patients with severe infections found that the standard qSOFA did not accurately predict severe maternal morbidity (ROC area under the curve [AUC] = 0.54, p = 0.49, sensitivity = 0.38, and specificity = 0.70). Pregnancy-specific modifications or “qSOFA-P” (respiratory rate [RR] ≥ 35 breaths/minute and systolic blood pressure [SBP] ≤ 85 mm Hg) significantly improved prediction of severe maternal morbidity (AUC = 0.77, p < 0.001, sensitivity = 0.79, and specificity = 0.74).

Conclusion The standard qSOFA is a poor screening tool in the prediction of severe maternal morbidity in pregnant patients with infections. A pregnancy-specific screening system, qSOFA-P, improved prediction of severe maternal morbidity in pregnant women with severe infections. Further prospective and large multicenter studies are needed to validate this scoring system in pregnant women.

Key Points

  • Validated scoring systems for evaluating pregnant patients with sepsis are needed.

  • Modifications to existing systems may improve the evaluation of pregnant patients with sepsis.

  • The qSOFA-P (RR ≥ 35 breaths/minute and SBP ≤ 85 mm Hg) includes modifications to qSOFA, and improves the detection of patients who would develop severe maternal morbidity..

Keywords

maternal infection - maternal morbidity and mortality - sepsis - qSOFA - qSOFA-P

Note

This study was presented at the 40th SMFM Annual Meeting—The Pregnancy Meeting, Friday, February 7, 2020; ID number: 59.




Publication History

Received: 04 November 2020

Accepted: 12 August 2021

Article published online:
28 September 2021

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