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DOI: 10.1055/s-0041-1736940
A novel triterpene glycoside from the sea cucumber Holothuria atra
Sea cucumbers are marine invertebrates, commonly used as food, or applied in traditional medicine in Asia. They are known as a rich source of triterpene glycosides.
In the current work, the black sea cucumber Holothuria atra Jaeger, one of the commercially important species in Indonesia, was studied. An 80% methanol crude extract was prepared and fractionated by means of column chromato-graphy (Diaion HP20). Semi-preparative HPLC-DAD-MS led to the isolation of two isomeric compounds.
Both compounds were submitted to extensive NMR, as well as HRMS analysis. The 13C-NMR data of compound 1 were in agreement with those of desholothurin B (desulphated holothurin B) [1]. While the HRMS data of compounds 1 and 2 did not differ significantly, differences were observed for the 13C-NMR data, especially for carbon signals of ring C. Based on 2D NMR, including NOESY, compound 2 was identified as a novel compound, the 12-epimer of 1, and was therefore named 12-epi-desholothurin B.
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The authors declare no conflict of interest.
Publikationsverlauf
Artikel online veröffentlicht:
13. Dezember 2021
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